Scientists Uncover New Anti-TB Compounds
ITHICA – Scientists from Weill Cornell Medical College have identified certain compounds that would inhibit the sophisticated mechanism used by tuberculosis bacteria for surviving dormant in infected cells.
The researchers said most of the people infected with TB remain symptom-free because the Mycobacterium tuberculosis, the disease-causing bacteria, is kept in check within immune system cells.
These cells produce compounds such as nitric oxide, which scientists believe damage or destroy the bacteria’s proteins. If these compounds are allowed to accumulate, the damaged proteins would kill the bacteria.
However, a protein-cleaving complex known as a proteasome breaks down that damaged proteins and allows the bacteria to remain dormant.
The researchers suggest that finding drugs to disable the proteasome would be a new way to fight TB.
During the study, the researchers examined 20,000 compounds for TB proteasome inhibition activity, and identified and synthesized a group of inhibitors, which they then tested for their ability to inhibit the proteasome inside the mycobacteria.
“We believe these findings represent a new approach for developing antibiotics in the fight against TB,” Nature magazine quoted Dr. Carl Nathan, senior author and chairman of the Department of Microbiology and Immunology, R.A. Rees Pritchett Professor of Microbiology and director of the Abby and Howard P.
Milstein Program in Chemical Biology of Infectious Disease at Weill Cornell Medical College, as saying
“This is important because we are running out of effective antibiotics that are currently available. There are few drugs that successfully combat TB in its dormant stage, which makes the bacterium so resilient in the body.
“More important, there are many antibiotics that kill bacteria by blocking the synthesis of proteins, but there are none that kill bacteria by interfering with protein breakdown, as we have found here,”
Tags: , alternative health, E-Care, E-Care Plan, health, health care, healthcare, herbal supplements, Herbs, home remedies, Medicine, nitric oxide, proteasome, proteins, TB, tea tree oil, teberculosis, Tele-Medicine, US Tele-Medicine
January 28th, 2010 at 4:58 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
January 29th, 2010 at 8:39 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 3rd, 2010 at 11:55 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 5th, 2010 at 4:06 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 6th, 2010 at 12:23 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 6th, 2010 at 11:14 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 6th, 2010 at 11:19 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 7th, 2010 at 1:16 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 7th, 2010 at 10:37 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 8th, 2010 at 1:40 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 8th, 2010 at 8:05 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 8th, 2010 at 8:39 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 10th, 2010 at 8:35 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 11th, 2010 at 1:53 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 11th, 2010 at 5:20 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 12th, 2010 at 2:03 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 12th, 2010 at 11:19 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 13th, 2010 at 3:57 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 13th, 2010 at 7:20 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 13th, 2010 at 8:00 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 14th, 2010 at 5:17 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 15th, 2010 at 4:34 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 15th, 2010 at 11:14 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 16th, 2010 at 11:15 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 19th, 2010 at 8:16 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 20th, 2010 at 2:57 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 20th, 2010 at 7:03 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 21st, 2010 at 7:04 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 21st, 2010 at 8:33 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 22nd, 2010 at 12:08 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 22nd, 2010 at 8:19 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 22nd, 2010 at 9:21 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 23rd, 2010 at 11:03 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 23rd, 2010 at 11:21 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 25th, 2010 at 2:46 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 25th, 2010 at 11:00 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 28th, 2010 at 6:49 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
February 28th, 2010 at 4:24 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 1st, 2010 at 10:08 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 1st, 2010 at 2:57 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 2nd, 2010 at 9:27 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 9th, 2010 at 10:16 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 11th, 2010 at 12:15 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 12th, 2010 at 4:37 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 12th, 2010 at 10:27 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 13th, 2010 at 6:36 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 13th, 2010 at 8:14 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 15th, 2010 at 3:52 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 15th, 2010 at 7:36 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 15th, 2010 at 5:13 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 16th, 2010 at 1:24 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 18th, 2010 at 1:12 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 18th, 2010 at 1:12 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 19th, 2010 at 12:16 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 20th, 2010 at 6:22 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 24th, 2010 at 5:55 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 24th, 2010 at 8:14 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 27th, 2010 at 4:07 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
March 29th, 2010 at 2:01 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 4th, 2010 at 4:54 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 9th, 2010 at 6:54 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 11th, 2010 at 5:01 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 11th, 2010 at 7:57 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 12th, 2010 at 1:24 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 12th, 2010 at 9:54 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 14th, 2010 at 2:04 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 16th, 2010 at 9:25 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 17th, 2010 at 11:42 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 18th, 2010 at 7:58 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 18th, 2010 at 8:08 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 19th, 2010 at 8:46 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 20th, 2010 at 12:11 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 20th, 2010 at 9:39 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 20th, 2010 at 9:39 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 21st, 2010 at 4:49 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 21st, 2010 at 4:49 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 24th, 2010 at 9:44 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 25th, 2010 at 12:18 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 26th, 2010 at 4:05 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
April 29th, 2010 at 5:39 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
May 4th, 2010 at 1:15 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
May 10th, 2010 at 9:56 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
May 18th, 2010 at 9:01 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
May 19th, 2010 at 10:51 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
May 22nd, 2010 at 7:44 am
Hello may I use some of the information here in this blog if I reference you with a link back to your site?
May 24th, 2010 at 10:10 pm
Trying to read your post. Your theme isnt working right using chrome.
June 3rd, 2010 at 11:20 am
…
Hi, thank you so much for these suggestions!…
June 3rd, 2010 at 1:27 pm
Thank you for your help!
June 11th, 2010 at 9:47 am
…
Hi there may possibly I reference some of the insight right here in this blog site if I reference you having a link back again in your website?…
June 17th, 2010 at 9:25 am
…
What a good resource!…
June 19th, 2010 at 2:43 am
A superb take on this you’ve gotten, while I do not go along with almost everything that is mentioned I can see your case.
July 1st, 2010 at 12:59 pm
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
July 4th, 2010 at 2:55 am
[...] US Tele-Medicine Blog » Blog Archive » Scientists Uncover New Anti … [...]
July 7th, 2010 at 8:28 am
I think you have a great page here… today was my first time coming here.. I just happened to find it doing a google search. anyway, good post.. I’ll be bookmarking this page for sure.
July 9th, 2010 at 3:05 am
I never would’ve had the idea to look at things this way. This is going to make my life a bunch easier.
July 10th, 2010 at 6:12 am
I totally am loving this post!!! absolutely gonna have to remember to put this on my bookmarks.
July 13th, 2010 at 7:15 am
Sort of on the same subject, brings me back to when I was only a young boy, when I was young i grew up on a farm where all of the tractors were green. I like Jd but for some cause I have always liked Farmall. Anyawy I am beginning to daydream now…good post I have provided it a DIGG.Com for you.
July 17th, 2010 at 12:43 pm
This is a great article. Thanks for the excellent information you shared! I was finding for this entry for a long time, but I was not able to see a reliable site.
July 17th, 2010 at 4:35 pm
I will post a link to this page on my site. I’m certain my visitors will find this info really great.
July 20th, 2010 at 11:20 am
Wuz up? Is there a way I can get email updates on this post?
July 20th, 2010 at 8:30 pm
This is an amazing blog post. Thank you very much for the excellent entry provided! I was looking for this information for a long time, but I wasn’t able to see a trusted source.
July 27th, 2010 at 7:15 am
Substantially, the post is actually the sweetest topic on curing acne naturally. I concur with your conclusions and will thirstily look forward to your future updates. Just saying thanks will not just be sufficient, for the tremendous lucidity in your writing. I will right away grab your rss feed to stay abreast of any updates.
July 27th, 2010 at 7:48 am
This is a good step to save paper. And will save the rain forests in Indonesia. Moreover, this will reduce the burden on the back of elementary school students. Of course this will make the traditional printing companies and governments in the third world into a panic because of their unpreparedness of information technology. . .
July 28th, 2010 at 12:17 am
I have been visiting variousblogs for my dissertation study. I have found your blog to be fairlybeneficial. Keep updating your blog with usefulinformation… Regards
July 28th, 2010 at 4:07 am
Hello… I can not access your rss feed… Something trouble? Can you fix it? Thanks
July 28th, 2010 at 6:57 am
Substantially, the post is actually the sweetest topic on curing acne naturally. I concur with your conclusions and will thirstily look forward to your future updates. Just saying thanks will not just be sufficient, for the tremendous lucidity in your writing. I will right away grab your rss feed to stay abreast of any updates.
July 28th, 2010 at 10:12 pm
Hey, I’m having a problem viewing your site in my browser. Could you please check this. My browser is Opera 7 btw.
July 28th, 2010 at 10:36 pm
I must say, I thought this was a pretty interesting read when it comes to this topic. Liked the material. . . . .
July 29th, 2010 at 12:47 am
…
Hi, exactly where did you get this info can you please assistance this with some proof or you may possibly say some good reference as I and others will genuinely value. This information is actually beneficial and I’ll say will usually be helpful if we…
July 29th, 2010 at 3:42 am
I enjoyed reading your interesting yet very informative insights. I am looking forward to reading more of your most recent articles and blogs.
July 29th, 2010 at 5:09 am
I wanted to thank you for this great read!! I definitely enjoying every little bit of it.I have you bookmarked to check out new stuff you post.
July 29th, 2010 at 9:50 pm
wow, nice post, I was wondering how to cure acne naturally. and found your site by yahoo, many userful stuff here, now i have got some idea. I’ve bookmark your site and also add rss. keep us updated.
July 29th, 2010 at 9:51 pm
Advantageously, the post is in reality the freshest topic on curing acne naturally. I concur with your conclusions and will thirstily look forward to your upcoming updates. Just saying thanks will not just be enough, for the phenomenal clarity in your writing. I will right away grab your rss feed to stay abreast of any updates.
July 29th, 2010 at 10:51 pm
I was just browsing for relevant blog posts for my project research and I happened to stumble upon yours. Thanks for the excellent information!
August 2nd, 2010 at 9:53 pm
Excellent read, I just passed this onto a colleague who was doing a little research on that. And he actually bought me lunch because I found it for him smile So let me rephrase that: Thanks for lunch!
August 2nd, 2010 at 10:53 pm
awesome post. I have discovered for myself just how flexible WP is, as a hosting platform for your website. you literally have everything you need to publish a website at your fingertips, through WordPress. thanks.
August 3rd, 2010 at 1:13 am
Where can I find this blog template? I want to use one thing comparable for the format of my blog.
August 4th, 2010 at 12:40 pm
Wow this takes me back. Nice blog.
August 12th, 2010 at 9:23 am
I liked reading this, like your blog design too. Is it wordpress?
August 13th, 2010 at 11:46 pm
wow, great, I was wondering how to cure acne naturally. and found your site by google, learned a lot, now i’m a bit clear. I’ve bookmark your site and also add rss. keep us updated.
August 15th, 2010 at 10:16 am
…
One particular on the top websites for relevant facts on this niche !…
August 16th, 2010 at 4:33 am
I’ll post a link to this page on my page. I am certain my readers will think of this info very great.
August 18th, 2010 at 4:12 am
Finally a smart blogger…I love how you are thinking and writing!
August 20th, 2010 at 6:05 am
Searching for this for some time now – i guess luck is much more advanced than search engines
August 24th, 2010 at 6:34 pm
Hmmm…very good to find out, there have been without a doubt many things that I had not notion of before.
August 25th, 2010 at 9:16 pm
You wouldn’t feel it but I’ve wasted all day digging for some posts about this. You happen to be a lifesaver, it was an very good read and has helped me out to no end. Cheers!
August 26th, 2010 at 3:48 pm
Cool entry thanks, sending this to my mates asap.
August 27th, 2010 at 5:40 pm
Great text and nice blog.
August 27th, 2010 at 10:32 pm
Thanks for another informative article. Where else would anyone get that kind of information in such a amazing way of writing.
August 28th, 2010 at 8:14 am
…
You guys possess a excellent blog site intending below, KIU!…
August 28th, 2010 at 9:01 am
…
Which is some inspirational things. Never knew that opinions might be this varied. Thank you for all the enthusiasm to provide such valuable info right here….
August 28th, 2010 at 6:01 pm
Very detailed info. I am very glad to I found this post. Thanks for sharing us great articles.
August 29th, 2010 at 10:31 pm
wicked webpage, this is going on my twitter.
August 30th, 2010 at 9:10 am
Hey, I just desired to let you know, I truly like the written substance on your website. But I am utilising Chromium on a machine running version 9.04 of Ubuntu and also the search and really feel aren’t very satisfying. Not a strong deal, I can still essentially understand the articles and search for info, but just wanted to inform you about that. The navigation bar is kind of challenging to use while using config I’m running. Maintain up the superb perform!
August 30th, 2010 at 12:19 pm
I just found your blog on Ask Jeeves, a really good read.
August 30th, 2010 at 6:53 pm
Cool, you’ll find in fact some very good points on this post some of my readers may come across this relevant, I am going to send a link, thank you.
August 30th, 2010 at 10:41 pm
tweet meme has you on their hot list for today ;D
August 31st, 2010 at 7:52 pm
FYI, your blog doesn’t look right in Opera.
September 1st, 2010 at 1:07 am
Hi webmaster – This is by far the best looking site I’ve seen. It was completely easy to navigate and it was easy to look for the information I needed. Fantastic layout and great content! Every site should have that. Awesome job
September 1st, 2010 at 1:47 pm
I truly agree with you concerning this matter. Nice post. Already bookmarked for future purposes.
September 1st, 2010 at 4:46 pm
I appreciate the informative post you share in your posts. I will bookmark your blog and have my children read in your blog frequently. I am really certain they’ll read a lot of new stuff in your blog than anybody else!
September 1st, 2010 at 7:45 pm
Thanks for the info provided! I was researching for this information for a long time, but I wasn’t able to see a reliable source.
September 2nd, 2010 at 6:29 am
I had fun reading this post. I want to read more on this topic.. Thanks for sharing this great article.. Anyway, I am going to subscribe to your rss and I wish you write great articles again soon.
September 2nd, 2010 at 10:01 am
I had fun reading this article. I need to read more on this topic.. Thank you for writing this great info.. Anyway, I am gonna subscribe to your feed and I wish you post again soon.
September 2nd, 2010 at 1:30 pm
Thank you for another great post. Where else would anyone get that kind of info in such a great way of writing.
September 2nd, 2010 at 4:50 pm
Thank you for another good entry. Where else could anybody get this kind of information in such a amazing way of writing.
September 2nd, 2010 at 9:33 pm
Thank you for providing great post regarding the subject. I am a fan of your site. Keep up the good job.
September 3rd, 2010 at 8:50 am
Hi Webmaster, commenters and everybody else !!! The blog was absolutely fantastic! Lots of great information and inspiration, both of which we all need!Keep ‘em coming… you all do such a great job at such Concepts… can’t tell you how much I, for one appreciate all you do!
September 3rd, 2010 at 11:59 am
…
Your place is valueble for me. Thanks!…