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Posts Tagged ‘bacteria’

Broccoli May Curb Crohn’s Progression

Tuesday, August 31st, 2010

Fibers from broccoli and plantain may help curb development of Crohn’s disease, researchers in Britain suggest.

Carol Roberts of the University of Liverpool and colleagues tested preparations of plant soluble fibers from leeks, apples, broccoli, plantains and the fat emulsifiers polysorbate 60 and 80 — commonly used in processed food manufacture.

The researchers found fiber foods inhibited invasion of the cells lining the bowel by bacteria — particularly a “sticky” type of Escherichia coli related to progression of Crohn’s disease.

The study, published in the journal Gut, finds 5 milligrams/milliliter of broccoli and plantains reduced invasion of E. coli by between 45 percent and 82 percent. Leek and apple fibers seem to have no impact but the emulsifier polysorbate 80 substantially encouraged the bacterial invasion process, the study says.

The results were confirmed in tissue samples taken from patients as they underwent surgery for other intestinal disorders.

“The findings suggest that supplementing the diet with broccoli/plantain fibers might prevent relapse of Crohn’s disease,” the authors say in a statement. “The results could have further implications for the treatment of Crohn’s disease as many enteral feeds — nutrition mixtures used for tube-feeding of patients — contain emulsifiers and could account for variable responses to this type of treatment.”

Diabetes: Sugar Smothers Body Immunity

Wednesday, August 25th, 2010

 Higher glucose levels in people with diabetes can form a sugar coating smothering the mechanisms the body used to fight infections, a British researcher says.

 Dr. Daniel Mitchell of the University of Warwick’s Medical School in England and colleagues found glucose in the blood is similar in structure to two sugars — mannose and fucose — found on bacteria and fungi that signal the body infection need to be combated.

 However, high levels of glucose can interfere with the binding of mannose and fucose by the specialized immune receptors and can inhibit these infection-fighting chemical processes. This interference may lead to chronic inflammatory disease and increased cardiovascular and kidney disease risks.

 The study, published in the journal Immunobiology, finds the specialized receptors that recognize bacteria and fungi associated molecules can become “blinded” by unhealthy glucose levels and suggests this may help explain why diabetic complications often include increased risk of viral infections such as influenza.

 ”Our findings offer a new perspective on how high glucose can potentially affect immunity and thus exert a negative impact on health,” Mitchell says in a statement. “It also helps to emphasize the importance of good diet on preventing or controlling diseases such as diabetes.”

Bacteria Are Gobbling Gulf Oil

Wednesday, August 25th, 2010

With the Deepwater Horizon spill finally choked off, researchers are hoping that marine microbes will help gobble up the millions of barrels of oil still lurking in the gulf. The first peer-reviewed study of the oil—published last week—suggested that the bugs weren’t doing much, however, at least in the plume that was analyzed. But a study published today, which takes a look at the microbes themselves, finds that oil-eating bacteria are flocking to the spill in droves, though it’s not clear how quickly they’re digesting it.

Bacteria consume oil more or less the way humans metabolize butter, says oceanographer Richard Camilli of Woods Hole Oceanographic Institution in Massachusetts, the lead author on last week’s report. They take in oxygen and hydrocarbons—the carbon-hydrogen molecules in the plume (which also appear in fatty foods like butter, margarine, and vegetable oil)—and spit them out as CO2 and biological waste. It’s something they’ve been doing for millennia in the Gulf of Mexico. “With all of the seepage, including the 40 to 50 million gallons a year that seep naturally into the gulf, we’d have oceans covered with oil slicks if they weren’t degrading,” says Alan Mearns, a Seattle, Washington–based National Oceanic and Atmospheric Administration marine ecologist, who was not affiliated with either study. Researchers hope that this process, called biodegradation, can help break up the oil contaminating the gulf now.

 To see if that is actually happening, a group of microbiologists from the University of California, Berkeley, pulled samples of seawater from a plume 1100 meters beneath the surface of the ocean—in the same location as one of the plumes detected by Camilli’s team—and the uncontaminated area surrounding it. Led by microbiologist Terry Hazen of UC Berkeley, the team looked at water both inside and outside the plume, analyzing its chemistry, physics, and even the DNA of its inhabitants. The results, published online today in Science, offer some reassurance: Ocean bacteria are aware of the oily invasion of their territory, and they’re responding accordingly.

 Hazen’s team found that microbes inside the plume samples were packed more than twice as densely as microbes outside it. Even more encouraging, the genes specifically geared to degrade hydrocarbons were more common in the plume as well, implying that it’s not just general bacteria that are taking on the plume. All in all, Hazen’s group predicts that, with the help of hungry microbes, the concentrations of the hydrocarbons his team analyzed in the plume could drop by half within a week.

 But that doesn’t mean the oil will be half gone in a week. The good news, according to Ronald Atlas, an oil microbiologist at the University of Louisville, Kentucky, is that the oil is definitely breaking up. “Microbes are clearly degrading the oil. The Hazen paper establishes that,” says Atlas, who was not involved in the study. “The question to resolve between the two studies is, what are the real rates of degradation?”

 Oil is made up of dozens of different hydrocarbon molecules. The ones Hazen analyzed—the alkanes—are generally the first to go, says Atlas. As for how long the rest will remain, it’s unclear. It all depends on how stable the oil emulsion—the giant glob formed when oil and water mix—turns out to be. If it disperses easily, the bacteria shouldn’t have much trouble. But if it holds together, Atlas says, they’ll have a harder time breaking it apart.

 Another concern has been that the oil-eating microbes could deplete oxygen within the plume. That’s because the bacteria must extract oxygen from the water around them, which could spell disaster for local fisheries trying to get back on their feet. But neither study detected a dangerous drop in oxygen within the plume. “It would be very hard to establish a dead zone in this plume just because of microbial degradation,” Camilli says.

 Mearns sees reason for optimism. He says with Hazen’s data and the rest of the data streaming in from elsewhere, scientists are now starting to think the oil will be gone much sooner than people thought before. “We’re talking days to months.”

Bacteria Can Help Build Durable Bone Implants

Sunday, February 28th, 2010


BIRMINGHAM – Can bacteria help build bones implants? Well, at least scientists at the University of Birmingham say “Yes”.

Lead researcher Lynne Macaskie suggests that Serratia bacteria that manufacture hydroxyapatite (HA) could be used to make stronger, more durable bone implants.

In a study, the researchers showed that the bacterial cells stuck tightly to surfaces like as titanium alloy, polypropylene, porous glass and polyurethane foam by forming a biofilm layer containing biopolymers that acted as a strong adhesive.

The HA coating then builds up over the surface. For practical use, the HA layer must stick tightly, then the material is dried and heated to destroy the bacteria.

With the help of micro-manipulation technique, the researchers measured the force needed to overcome the bioglue adhesion, and showed that dried biofilm stuck 20-times more tightly than fresh biofilm.

When coated with HA the adhesion was several times more again. Slightly roughening the surface made the bioglue much more effective.

Presently, implant materials are made by spraying-on hydroxyapatite. This does not have good mechanical strength and the spraying only reaches visible areas.

The new biocoating method reaches all the hidden surfaces as the bacteria can “swim” into hidden nooks and crannies.

Macaskie insists that bacterial HA has better properties than HA made chemically as the nanocrystals of HA produced by the bacteria are much smaller than HA crystals produced chemically, giving them a high mechanical strength.

“The bacteria are destroyed by heating, leaving just the HA stuck to the surface with their own glue – rather akin to a burnt milk-saucepan,” said Macaskie.

“We need to do more work actually to turn the materials into materials we can use in biomedicine and the environment,” she added.

The study was presented at Society for General Microbiology’s meeting at Heriot-Watt University, Edinburgh.

Home Remedies Series – Pyorrhoea

Saturday, February 20th, 2010


Pyorrhoea is triggered by bacterial activity. A thin layer of harmful bacteria is continuously building up on our teeth. If it is not removed by tooth-cleansing, especially after meals, it forms an organised mass on the tooth surface in a short time. This is referred to as a ‘bacterial plaque’. When accumulated, bacteria in plaque produce many toxins which irritate the gums, causing them to become inflamed, tender, and prone to bleeding easily. The bacterial activity is, however, facilitated by the lowered vitality of the system

Injury to gums, incorrect brushing and improper use of tooth picks

Other factors contributing to the development of pyorrhoea include injury to the gums and supporting structures by physical and chemical irritants in the mouth, incorrect brushing, stagnation of food particles, and improper use of tooth picks

Pyorrhoea treatment using Guava

Chewing unripe guava is an excellent tonic for the teeth and gums. It stops the bleeding from the gums due to its styptic effect and richness in vitamin C. Chewing the tender leaves of the guava tree also helps in curing bleeding from the gums and keeps the teeth healthy. A decoction of root-bark can also be beneficially used as a mouthwash fur swollen gums

Pyorrhoea treatment using Lemon and Lime

The regular use of lemon and lime is useful in pyorrhoea due to their high vitamin C content. They strengthen the gums and teeth, and are very effective in preventing and curing acute inflammations of the gum margins

Pyorrhoea treatment using Orange

The use of orange has also been found beneficial in the treatment of pyorrhoea. This fruit should be eaten regularly and its skin rubbed over the teeth and gums. This will improve the condition

Pyorrhoea treatment using Pomegranate Rind

Powder of the dry rind of pomegranate, mixed with pepper and common salt, can be applied as a very good dentifrice. Its regular application strengthens the gums, stops bleeding, and prevents pyorrhoea

Pyorrhoea treatment using Spinach Juice

The juice of raw spinach is another valuable remedy for the prevention and treatment of pyorrhoea because of its beneficial effect on the teeth and gums. This effect is greatly enhanced if spinach juice is taken in combination with carrot juice. Both spinach juice and carrot juice should be taken in quantities of 125 ml each daily. A permanent aid for this affliction has been found in the use of natural raw foods, and in drinking an ample quantity of carrot and spinach juice

Pyorrhoea treatment using Lettuce

Lettuce has proved useful in preventing pyorrhoea The leaves of this vegetable should be chewed everyday immediately after meals for this purpose

Pyorrhoea treatment using Wheat

Wheat is especially valuable in the prevention and treatment of pyorrhoea. Wheat wheat tortilla are usually taken with other foods, and hence, the other food also gets chewed properly. This not only provides the needed exercise for the teeth and gum but also aids in digestion

Fruit juice and fruit diet

The patient should begin the treatment with a short juice fast for three to five days. Oranges and carrot should be used for juices. After the juice fast, the patient should spend the next three to five days on an exclusive fresh fruit diet, taking three meals a day of juicy fruits

Balanced diet

Thereafter he may gradually embark upon a balanced diet, with emphasis on fresh fruits, green salads, whole-meal bread, properly cooked vegetables, cheese, nuts, and milk

White bread,refined food, condiments, meat etc should be avoided

White bread, white sugar, and all refined and tinned foods must he completely given up. Condiments, sauces, alcohol, coffee, and strong tea, as well as meat and other fresh foods should also be avoided

Other Pyorrhoea treatment

Warm-water enema and a hip bath

During the juice fast, the bowels should be cleansed daily with a warm-water enema. Daily dry friction and a hip bath should be taken

Breathing exercises and hot Epsom salts bath

Breathing and other exercises, should form a part of the morning routine. A hot Epsom salts bath taken twice weekly will also be beneficial

Scientists Develop Better Technique to Study Bacterial Swimming

Monday, February 1st, 2010


CHICAGO – Scientists have come up with a new way to watch bacteria as they swim, which is expected to eventually help trap Escherichia coli bacteria and modify the microbes’ environment without hindering the way they move.

The new approach uses optical traps, microfluidic chambers and fluorescence to get an improved picture of how E. coli get around.

Yann Chemla, a professor of Physics at the University of Illinois, says that the microfluidic chambers provide a controlled environment in which the bacteria swim, and allow them to introduce specific stimuli – such as chemical attractants – to see if the microbes change direction in response to that stimulus.

Chemla, who jointly led the study with physics professor Ido Golding, further says that optical traps use lasers to confine individual cells without impeding their rotation or the movement of their flagella.

The researcher calls the optical traps “bacterial treadmills”.

According to the researchers, movement of the bacterial cell alters the light from the laser, and, thereby, help track its behaviour.

Fluorescent markers enhance visualization of the bacteria and their flagella under a microscope, say the researchers.

While earlier studies have been unable to follow individual bacterial cells moving in three dimensions for more than about 30 seconds, the new approach allows the researchers to track a single bacterium as it swims for up to an hour, and that is why it may offer a new look at questions that so far have been unanswerable.

“For example, some people have asked whether E. coli has a nose. Does it have a front and back?” Nature magazine quoted Golding as saying.

He and his colleagues have observed that while the bacterium can travel in either direction, most E.coli have “a pronounced preference” for one over the other.

The researchers found that after most tumbles, a bacterium usually continued swimming in the same general direction, but that about one in six tumbles caused it to change direction completely.

They were also able to quantify other features of bacterial swimming, such as changes in velocity and the time spent running and tumbling.

They hope that their novel method will allow scientists to address many more questions about this model organism.

“That’s the typical way biology moves forward. You develop a new measurement capability and then you can use that to go back and look at fundamental questions that people had been looking at but had no way of answering,” Golding said.

A research article describing the new technique has been published in the journal Nature Methods.

 

Bacteria Can Help Convert Waste to Power

Tuesday, January 19th, 2010


Bacteria Can Help Convert Waste to Power

BOSTON – Bacteria that generate power could be used in microbial fuel cells to convert waste into electricity, according to the latest research.

University of Massachusetts (U-M) researchers isolated bacteria with large numbers of tiny projections called pili which transfer electrons to generate power in fuel cells, more efficiently than counterparts with a smooth surface.

The researchers isolated a strain of Geobacter sulfurreducens which they called KN400 that grew prolifically on the graphite anodes of fuel cells.

The bacteria formed a thick bio-film on the anode surface, which conducted electricity. The researchers found large quantities of pilin, a protein that makes the tiny fibres that conduct electricity through the sticky bio-film.

“The filaments form microscopic projections called pili that act as microbial nanowires,” said Derek Lovley, U-M professor. “Using this bacterial strain in a fuel cell to generate electricity would greatly increase the cell’s power output.”

Microbial fuel cells can be used in monitoring devices in environments where it is difficult to replace batteries if they fail but to be successful they need to have an efficient and long-lasting source of power.

Lovley described how KN400 might be used in sensors placed on the ocean floor to monitor migration of turtles.

These findings were reported at the Society for General Microbiology’s meeting at Heriot-Watt University, Edinburgh

Scientists Uncover Vulnerable Enzyme that Can be Targeted to Kill Dangerous Pathogens

Wednesday, January 13th, 2010


Scientists Uncover Vulnerable Enzyme that Can be Targeted to Kill Dangerous Pathogens

BALTIMORE – A collaborative study conducted by researchers from three institutions in the U.S. has shown that an enzyme, which is essential to many bacteria, can be targeted to kill dangerous pathogens.

Experts at Burnham Institute for Medical Research (Burnham), University of Texas Southwestern Medical Center and University of Maryland have also identified chemical compounds that can inhibit this enzyme, and suppress the growth of pathogenic bacteria.

Writing about their study in the journal Chemistry and Biology, the researchers say that their findings are essential to develop new broad-spectrum antibacterial agents to overcome multi-drug resistance.

Dr. Andrei Osterman, an associate professor in Burnham’s ioinformatics and Systems Biology program, targeted the acterial nicotinate mononucleotide adenylyltransferase (NadD), an essential enzyme for nicotinamide adenine dinculeotide (NAD) biosynthesis, which has many crucial functions in nearly all important pathogens.

The bacterial NadD differs significantly from the human enzyme.

“It’s clear that because of bacterial resistance, we need new, wide-spectrum antibiotics. This enzyme is indispensable in many pathogens, so finding ways to inhibit it could give us new options against infection,” said Dr. Osterman.

The research team used a structure-based approach to search for low-molecular-weight compounds that would selectively inhibit bacterial NadD, but not the human equivalent, by screening, in silico, more than a million compounds.

In their experiments, they tested the best predicted compounds against Escherichia coli and Bacillus anthracis (anthrax), which led them to a handful of versatile inhibitory chemotypes, which they explored in detail.

Using protein crystallography, a 3D structure of the enzyme in complex with one of the inhibitors was solved providing guidelines for further drug improvement.

“This is proof-of-concept that NadD is a good target to create antibacterial agents. This knowledge will be useful for both biodefense and public health. The next step is to find better inhibitors. We do not have a silver bullet yet, but we are certainly hitting a golden target,” said Dr Osterman.

The research was supported by a grant from the National Institute of Allergy and Infectious Diseases.

How Do Bacteria Subvert Healthy Cells?

Wednesday, January 6th, 2010


ORLANDO – A microbiologist has uncovered an unknown mechanism that helps a deadly food-borne bacterium subvert healthy cells.

Listeria monocytogenes is a bacterium that can cause pregnant women to lose their foetuses and can trigger meningitis fatalities among the elderly or people with compromised immune systems.

The bacterium has been linked to outbreaks traced to food processing plants in the US and Canada. Those cases in eight states were linked to people eating contaminated sliced turkey meat.

Scientists have long known that Listeria spreads from one human cell to another. Bacteria growing in one cell move fast enough to create a finger-like structure that protrudes from the cell and pushes into an adjacent cell. The bacteria then infects the adjacent cell.

Keith Ireton, microbiology professor at the University of Central Florida (UCF) and his team have discovered a previously unknown second process that gradually overwhelms the second cell’s ability to defend itself from infection.

The plasma membrane, or outer layer, of healthy human cells normally exhibits tension. Such tension might be expected to prevent Listeria from spreading to adjacent uninfected cells.

However, Ireton’s lab found that a Listeria protein called InlC appears to relieve tension at the plasma membrane in infected cells, making it easier for moving bacteria to deform the membrane and then spread into adjacent, healthy cells.

“Our discovery could have relevance for bacterial pathogens that cause Shigellosis or Rocky Mountain spotted fever, as these bacteria resemble Listeria in their ability to move inside the host cell and spread,” Ireton says.

The report features in Nature Cell Biology.

Scientists Watch Evolution Unfold In a Bottle

Sunday, January 3rd, 2010


DETROIT  - Scientists now have physical proof of how species evolve and the fittest survive, after a 21-year study in which they documented the evolution of single-celled E. coli bacteria over 40,000 generations.

Richard Lenski, Hannah professor of microbial ecology at Michigan State University (MSU), said: “It’s extra nice now to be able to show precisely how selection has changed the genomes of these bacteria, step by step over tens of thousands of generations.”

 

Lenski’s team periodically froze bacteria for later study, and technology has since developed to allow complete genetic sequencing. By the 20,000-generation midpoint, researchers discovered 45 mutations among surviving cells in the bottled bacteria.

Those mutations, according to Darwin’s theory, should have conferred some advantage, and that’s exactly what the researchers found.

The results “beautifully emphasise the succession of mutational events that allowed these organisms to climb toward higher and higher efficiency in their environment”, noted Dominique Schneider, molecular geneticist at the Universit Joseph Fourier in Grenoble, France.

Lenski’s long-running experiment itself is uniquely suited to answer some critical questions — such as whether rates of change in a bacteria’s genome move in tandem with its fitness to survive.

A mutation involved in DNA metabolism arose around generation 26,000, causing the mutation rate everywhere else in the genome to increase dramatically.

The number of mutations jumped to 653 by generation 40,000, but researchers surmise that most of the late-evolving mutations were not helpful to the bacteria, said an MSU release.

Gene mutations involved in human DNA replication are involved in some cancers. Many of the patterns observed in the experiment also occur in certain microbial infections, “and cancer progression is a fundamentally similar evolutionary process”, observed collaborator Jeffrey Barrick.

“So what we learn here can help us better understand the course of these diseases.”

The paper involved collaboration with scientists from South Korea as well as France and MSU.

The findings were published in Nature.

Bacteria Can Transform Minerals Electrically

Sunday, December 27th, 2009


LONDON – Got a messy cleanup problem that requires a molecule-by-molecule fix? Instead of nanotech, how about deploying an array of ready-made, versatile bacteria? Scientists studying a genus of the rock-dwelling bacteria called Shewanella have found out how the organisms can transform minerals by zapping them with tiny electrical currents. The discovery could lead to new types of fuel cells to generate electricity, to better environmental-cleanup techniques, and possibly even to a new generation of organically made materials.

Bacteria live in almost every environment on Earth, from the ocean’s deepest trenches to the Himalayas’ highest peaks. Perhaps the main reason is their supreme adaptability. Animals use oxygen as part of metabolism. But some microbes can thrive in the absence of oxygen, something that has puzzled scientists for nearly half a century. Even when scientists finally discovered that the organisms were using rocks instead of oxygen to purge electrons, they still couldn’t figure out the exact molecular mechanism that made such metabolism possible.

Now, after 5 years of studies in laboratories in the United States and the United Kingdom, a team has discovered the elusive process. It turns out that Shewanella use a class of proteins on their surface that functions like an electrical wire between the bacteria’s interior and exterior. The proteins–called deca-heme c-class cytochromes–bond with the rock molecules and convey electrons out through the cell membrane, the composition of which normally functions as an insulator. The process also chemically alters the rock, releasing elements such as iron and manganese, the team reports online this week in the Proceedings of the National Academy of Sciences.

“As a geochemist, I was surprised to see just how much ‘machinery’ the microbe builds to move electrons,” says co-author Susan Brantley of Pennsylvania State University, University Park. She says that mechanism could be the key to using Shewanella and related bacteria in activities such as electricity production and oil-spill cleanup. Lab experiments have shown that other kinds of bacteria can generate an electrical current. Likewise, bacteria over time will clean up oil spills. The new research, Brantley explains, could lead to cheaper and more efficient ways to do both by tweaking the bacteria’s metabolism.

The fact that Shewanella live underground naturally makes them ideal candidates for environmental-cleanup tasks, says biochemist and lead author David Richardson of the University of East Anglia in the United Kingdom. “Understanding their biochemistry could help to develop strategies to stimulate their activities [at the cleanup sites],” he says.

The findings provide, “finally, the hard-core biochemical information that explains how these kinds of metabolic reactions can take place,” says geochemist Eric Roden of the University of Wisconsin, Madison. It is “the full explanation that people in many disciplines have been waiting for,” he says.

 

Scientists Identify Bacterium That Helps in Formation of Gold

Sunday, December 13th, 2009


SYDNEY – Australian scientists have found that the bacterium Cupriavidus metallidurans catalyses the biomineralisation of gold by transforming toxic gold compounds to their metallic form using active cellular mechanism.

According to Frank Reith, leader of the research and working at the University of Adelaide, “A number of years ago we discovered that the metal-resistant bacterium Cupriavidus metallidurans occurred on gold grains from two sites in Australia.

“The sites are 3500 km apart, in southern New South Wales and northern Queensland, so when we found the same organism on grains from both sites we thought we were onto something,” he said.

“It made us wonder why these organisms live in this particular environment. The results of this study point to their involvement in the active detoxification of Au complexes leading to formation of gold biominerals,” he added.

The experiments showed that C. metallidurans rapidly accumulates toxic gold complexes from a solution prepared in the lab.

This process promotes gold toxicity, which pushes the bacterium to induce oxidative stress and metal resistance clusters as well as an as yet uncharacterized Au-specific gene cluster in order to defend its cellular integrity.

This leads to active biochemically-mediated reduction of gold complexes to nano-particulate, metallic gold, which may contribute to the growth of gold nuggets.

By determining what elements there are, scientists can see where the gold is located in relation to the cells.

For this study, scientists combined synchrotron techniques at the European Synchrotron Radiation Facility (ESRF) and the Advanced Photon Source (APS) and molecular microbial techniques to understand the biomineralisation in bacteria.

It is the first time that these techniques have been used in the same study, so Frank Reith brought together a multinational team of experts in both areas for the success of the experiment.

This is the first direct evidence that bacteria are actively involved in the cycling of rare and precious metals, such as gold.

These results open the doors to the production of biosensors.

 

“The discovery of an Au-specific operon means that we can now start to develop gold-specific biosensors, which will help mineral explorers to find new gold deposits,” said Reith.

How Silver is Used in Wellness

Thursday, December 10th, 2009


BEVERLY HILLS – Silver has been used for medicinal purposes for centuries and, in modern times, several prescription drugs contain the precious metal. For example, silver nitrate is used to prevent the eye condition conjunctivitis (inflammation of the conjunctiva, the clear membrane that covers the white part of the eye and the inner surface of the eyelids) in newborn babies and it treats corns and warts, too. Another medication, silver sulfadiazine (sold as Silvadene) contains a micronized form of silver that is applied topically to the body to treat burns. And now researchers have found that when silver is used with copper, the combination may offer protection against the majority of serious hospital-acquired infections.

The germ-killing properties of copper, like those of silver, have been recognized for hundreds of years. Scientists have discovered that copper ions are deadly to bacteria because they penetrate the micro-organisms and disrupt molecular pathways that are important for their survival. In fact, in 2008 the U.S. Environmental Protection Agency (EPA) officially registered copper alloys and allowed them to be marketed with the label “kills 99.9% of bacteria within two hours”.

Scientist Dana Filoti successfully tested her hypothesis that the combination of silver and copper would work better to kill bacteria than the metals alone. She created zeolite (a porous mineral) ceramic structures to hold the metals. “The hard ceramic structure looks like Swiss cheese and inside the holes there are ions of silver and copper,” Filoti explained in a statement to the press. By experimenting with the ratio of copper to silver and the texture of extremely thin films containing the metals, she was able to almost totally wipe out all microbes on the surface.

Filoti, a University of New Hampshire physicist, presented her findings at the recent national meeting of the American Vacuum Society (AVS), an organization that promotes the science and technology of materials, interfaces and processing, held in San Jose, California. Filoti unveiled her copper/silver films and told the group of scientists and engineers that silver and copper do work synergistically to effectively kill bacteria, including the type of pathogens that too often cause difficult-to-treat infections acquired in hospitals.

A practical application of the silver and copper combo’s amazing ability to kill germs is on the horizon. Filoti is working with a New Hampshire company to design an antimicrobial face mask that will protect wearers against pathogens known to cause many hospital-acquired infections.

Light, Photosynthesis Harmful to Fresh Produce

Thursday, November 19th, 2009


TEL-AVIV –  A study conducted by Israeli researchers suggests that exposure to light, and possibly photosynthesis, may help disease-causing bacteria to invade fresh produce, making them impervious to washing.

According to background information in a report published in journal Applied and Environmental Microbiology, past studies have already shown that salmonella enterica attaches to the surface of fresh produce, and finds its way below the surface of the skin through pores called stomata, where it can hide from and resist washing and food sanitizers.

In the new study, researchers from the Agricultural Research Organization at the Volcani Center in Israel and Tel-Aviv University examined the role that light and photosynthesis might play on the ability of salmonella bacteria to infiltrate lettuce leaves via stomata.

They exposed sterile iceberg lettuce leaves to bacteria either in the light, in the dark, or in the dark after 30 minutes of exposure to light.

Incubation in the light or pre-exposure to light resulted in aggregation of bacteria around open stomata and invasion into the inner leaf tissue.

Incubation in the dark, on the other hand, resulted in a scattered attachment pattern and very little internalization.

According to the researchers, the increased propensity for internalization in the light may be due to several factors.

First, they say, in the absence of light plants enter a period of dormancy, where stomata are closed and no photosynthesis takes place. In the light, the stomata are open.

Additional findings also suggest that the bacteria are attracted to the open stomata by the nutrients produced during photosynthesis, which are not present in the dark.

“The elucidation of the mechanism by which Salmonella invades intact leaves has important implications for both pre- and postharvest handling of lettuce and probably other leafy vegetables. The capacity to inhibit internalization should limit bacterial colonization to the phylloplane and consequently might enhance the effectiveness of surface sanitizers,” say the researchers.

Fashion and Beauty Trends in Fall Takes Toll on Health

Monday, November 16th, 2009


WASHINGTON – While women are all set to bid adieu to their summer wear, and get ready to shop for the latest fashion gear for fall, experts have advised them to be aware of fashion and beauty trends that may be harmful to their health.

Shazia Khan, co-medical director, Loyola Primary Care Center at Oakbrook Terrace, Loyola University Health System (LUHS), has cited many dangerous fashion and beauty trends that include large bags or purses, high-heeled shoes, nickel jewelery and acrylic nails.

“Women can pay a high price for fashion when it comes to their health. Certain beauty and fashion trends can take their toll, if women do not take steps to correct them,” she said.

The harmful fashion trends and their effects on health are as follows:

Bags

Large purses or bags may be to blame for back and neck pain, because they place a strain on the shoulders and neck. Avoid bags that weigh more than 10 pounds.

Khan has recommended that women should look for small purses made with light material or backpacks where weight is distributed evenly across the back and shoulders.

If women cannot bear to part with oversized bags or purses, they should incorporate neck, back and shoulder strength-training exercises into their workout routines. They also should regularly rotate the shoulder on which they carry the bag.

Big bags and purses also are a target for harmful bacteria such as E. coli and Staphylococcus aureus.

High Heels

Continuously using the stylish stilettos can lead to long-term foot, back and ankle problems.

Women who insist on wearing high heels should take heed and limit the time they wear them to prevent long-term damage.

Other than that women should alternate the height of heels in order to prevent the Achilles tendon from tightening and shortening.They should choose a wider, more stable heel and never wear a heel that causes imbalance.

Choose a shoe that allows ample room for the toes and only wear pointed toes that narrow well past the ball of the foot. And always go shoe shopping at the end of the day to allow for normal daily swelling.

Jewelry

Hypersensitivity to the nickel in jewellery can cause a chronic itchy, red-skin reaction.

People who are highly sensitive to nickel should have their jewellery lacquered, coated or plated with palladium to protect the direct contact of nickel with the bare skin. Another option is to strictly wear stainless steel, platinum, or gold jewellery.

Acrylic Nails

When an acrylic nail is applied to the natural nail surface, minor trauma to the acrylic nail can cause separation of the nail from its nail bed.

“Acrylic nails allow bacteria and fungus to enter the nail area, which can lead to infection. A better option would be to take care of the original nail through moisturizing and strengthening polish,” said Khan.

She concluded that women could find ways to be stylish without compromising their health.

“These trends can have legitimate, long-term health ramifications. Using these tips will allow women to remain fashion forward without jeopardizing their health down the road,” said Khan.


Experts Map the Body’s Bacteria

Friday, November 6th, 2009



 

BOULDER – Scientists have developed an atlas of the bacteria that live in different regions of the human body.

Some of the microbes help keep us healthy by playing a key role in physiological functions.

The University of Colorado at Boulder team found unexpectedly wide variations in bacterial communities from person to person.

The researchers hope their work, published in Science Express, will eventually aid clinical research.

They say that it might one day be possible to identify sites on the human body where transplants of specific microbes could benefit health.

The study was based on an intensive analysis of the bacteria found at 27 separate sites on the bodies of nine healthy volunteers.

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BODY SITES ANALYZED

Forehead

Armpits

Head hair

Ear canal

Forearm

Palm

Index finger

Navel

Back of the knee

Soles of the feet

Nostrils

Mouth

Gut

Not only did the bacterial communities vary from person to person, they also varied considerably from one site on the body to another, and from test to test – but some patterns did emerge.

What is healthy?

Lead researcher Dr Rob Knight said: “This is the most complete view we have yet of the microbial side of ourselves, one that our group and others will be adding to over the coming years.

“The goal is to find out what is normal for a healthy person, which will provide a baseline for further studies to look at people with diseased states.”

There are an estimated 100 trillion microbes living on or inside the human body.

They are thought to play a key role in many physiological functions, including the development of the immune system, digestion of key foods and helping to deter potentially disease-causing pathogens.

The researchers took four samples from each volunteer over a three-month period – usually one to two hours after they had showered.

They used the latest gene sequencing and computer techniques to draw up a profile of the microbes found at each specific site.

Most sites showed big variations in the bacteria they harboured from test to test even within the same individual.

However, there was less variation in the bacteria found in the armpits and soles of the feet – possibly because they provide a dark, moist environment.

The least variation of all was found in the mouth cavity.

Skin sites in the head area, including the forehead, nose, ear and hair, were dominated by one specific type of bacteria.

Sites on the trunk and legs were dominated by a different group.

Researcher Dr Noah Fierer said: “We have an immense number of questions to answer.

“Why do healthy people have such different microbial communities?

“Do we each have distinct microbial signatures at birth, or do they evolve as we age? And how much do they matter?”

Transplant test

The researchers disinfected the forearms and foreheads of some volunteers, and “inoculated” both sides with bacterial communities from the tongue.

The tongue bacteria lasted longer on the forearms than foreheads.

Dr Elizabeth Costello, who also worked on the study, said: “It may be that drier areas of the skin like forearms make generally more hospitable landing pads for bacteria.”

A previous study by the same examined the bacteria on 102 human hands.

In total, they identified more than 4,200 species of bacteria, but only about five were shared by all 51 participants.

Dr Knight said understanding the variation in human microbial communities held promise for future clinical research.

“If we can better understand this variation, we may be able to begin searching for genetic biomarkers for disease,” he said.

“Because our human genomes vary so little but our repertoire of microbial genes vary so much, it makes sense to look for variations that correlate with disease at specific locations.”