Tramadol - generic name for Ultram and ‘drug hydrochloride. Relieves pain and is’ a good alternative to drugs narcotic painkillers. Nowadays, this drug is’ one of the most ‘commonly prescribed as an alternative to more’ strong analgesic drugs.
Function
Tramadol or Ultram are painkillers very popular used to treat moderate and severe pain. Not ‘a narcotic drug, but despite this’ create addiction and dependence especially in the elderly population, to which this drug is commonly prescribed.
The last increase of dose and ‘between 50 and 100 mg every 4-6 days depending on the needs’, with a maximum daily dose of 400 mg.The manufacturer of Tramadol, recommended doses are very specific for this drug: for adults, the initial dose and ‘25 mg capsules in the morning, this dose may’ be increased by 25 mg every three days , up to a maximum dose of 100 mg per day. Upon reaching this dose, the patient may ‘receive additional requirement in which you increase the dose of 50 mg every three days, up to 200 mg of dose per day. In elderly patients, and ‘important to maintain a mix that does not exceed 300 mg per day. the limitation period should be increased in intervals of every 12 hours to a maximum of 200 mg daily. In patients with cirrhosis (liver disease), the tramadol 50mg capsules should apply every 12 hours.
Considerations
Tramadol can ‘increase levels of liver enzymes and can’ lead to decreased levels of creatinine and hemoglobin, what ‘and’ potentially toxic due to the effect that Tramadol liver. It ‘must therefore monitor these levels regularly. Use caution in patients with inhibited by serotonin (SSRIs) because Tramadol can ‘increase the risk for serotonin syndrome.
Warnings
People allergic to opioids or women pregnant or lactating women should not take this medication. Tramadol in its initial use can ‘create allergic reactions, therefore, patients should be closely followed. People who have reactions anapilattiche from codeine or other opioids are more ‘at risk of suffering an allergic reaction to Tramadol. Also there is’ risk of respiratory complications in patients who have suffered injuries to his head, or have kidney or liver problems, so these people should not use this drug.
Monitoring
The level of pain should be checked every 30 minutes after the use of Tramadol. If the degree breathing down over 12 breaths per minute, the prescription drug should be ’stopped and’ need to consult with your doctor.
In addition, there are cases of constipation due to use of Tramadol in case this situation more than three days, we must consider the use of laxatives. Patients should be followed in order to avoid dependency, but at the same time and ‘important not to stop this drug in a sudden, since you can create withdrawal symptoms in patients. The use of any medicine that does not need ‘recipe with Tramadol and’ to check with your doctor to avoid undesirable interactions.
Some online pharmacy can assist you to buy tramadol online without prescription.you can order no prescription tramadol at your leisure, whenever and wherever you wish.
We have never posted an article like this, however if there was ever an exception to promote spiritual and holistic wellness, this is it.
This is a wonderful piece by MichaelGartner, editor of newspapers large and small and past president of NBC News. In 1997, he won the Pulitzer Prize for editorial writing. It is well worth reading, and a few good chuckles are guaranteed. Here goes….
My father never drove a car. Well, that’s not quite right. I should say I never saw him drive a car.
He quit driving in 1927, when he was 25 years old, and the last car he drove was a 1926 Whippet.
“In those days,” he told me when he was in his 90s, “to drive a car you had to do things with your hands, and do things with your feet, and look every which way, and I decided you could walk through life and enjoy it or drive through life and miss it.”
At which point my mother, a sometimes salty Irishwoman, chimed in: “Oh, bull—-! she said. ”He hit a horse.”
“Well,” my father said, “there was that, too.”
So my brother and I grew up in a household without a car. The neighbors all had cars — the Kollingses next door had a green 1941 Dodge, the VanLaninghams across the street a gray 1936 Plymouth, the Hopsons two doors down a black 1941 Ford — but we had none.
My father, a newspaperman in Des Moines , would take the streetcar to work and, often as not, walk the 3 miles home. If he took the streetcar home, my mother and brother and I would walk the three blocks to the streetcar stop, meet him and walk home together.
My brother, David, was born in 1935, and I was born in 1938, and sometimes, at dinner, we’d ask how come all the neighbors had cars but we had none. ”No one in the family drives,” my mother would explain, and that was that.
But, sometimes, my father would say, “But as soon as one of you boys turns 16, we’ll get one.” It was as if he wasn’t sure which one of us would turn 16 first.
But, sure enough, my brother turned 16 before I did, so in 1951 my parents bought a used 1950 Chevrolet from a friend who ran the parts department at a Chevy dealership downtown.
It was a four-door, white model, stick shift, fender skirts, loaded with everything, and, since my parents didn’t drive, it more or less became my brother’s car. Having a car but not being able to drive didn’t bother my father, but it didn’t make sense to my mother.
So in 1952, when she was 43 years old, she asked a friend to teach her to drive. She learned in a nearby cemetery, the place where I learned to drive the following year and where, a generation later, I took my two sons to practice driving. The cemetery probably was my father’s idea. ”Who can your mother hurt in the cemetery?” I remember him saying more than once.
For the next 45 years or so, until she was 90, my mother was the driver in the family. Neither she nor my father had any sense of direction, but he loaded up on maps — though they seldom left the city limits — and appointed himself navigator.. It seemed to work.
Still, they both continued to walk a lot. My mother was a devout Catholic, and my father an equally devout agnostic, an arrangement that didn’t seem to bother either of them through their 75 years of marriage.
(Yes, 75 years, and they were deeply in love the entire time.)
He retired when he was 70, and nearly every morning for the next 20 years or so, he would walk with her the mile to St.Augustin’s Church. She would walk down and sit in the front pew, and he would wait in the back until he saw which of the parish’s two priests was on duty that morning. If it was the pastor, my father then would go out and take a 2-mile walk, meeting my mother at the end of the service and walking her home.
If it was the assistant pastor, he’d take just a 1-mile walk and then head back to the church. He called the priests “Father Fast” and “Father Slow.”
After he retired, my father almost always accompanied my mother whenever she drove anywhere, even if he had no reason to go along. If she were going to the beauty parlor, he’d sit in the car and read, or go take a stroll or, if it was summer, have her keep the engine running so he could listen to the Cubs game on the radio. In the evening, then, when I’d stop by, he’d explain: “The Cubs lost again. The millionaire on second base made a bad throw to the millionaire on first base, so the multimillionaire on third base scored.”
If she were going to the grocery store, he would go along to carry the bags out — and to make sure she loaded up on ice cream. As I said, he was always the navigator, and once, when he was 95 and she was 88 and still driving, he said to me, “Do you want to know the secret of a long life?”
“I guess so,” I said, knowing it probably would be something bizarre.
“No left turns,” he said.
“What?” I asked.
“No left turns,” he repeated. ”Several years ago, your mother and I read an article that said most accidents that old people are in happen when they turn left in front of oncoming traffic..
As you get older, your eyesight worsens, and you can lose your depth perception, it said. So your mother and I decided never again to make a left turn.”
“What?” I said again.
“No left turns,” he said. ”Think about it. Three rights are the same as a left, and that’s a lot safer So we always make three rights.”
“You’re kidding!” I said, and I turned to my mother for support. ”No,” she said, “your father is right. We make three rights. It works.” But then she added: “Except when your father loses count.”
I was driving at the time, and I almost drove off the road as I started laughing.
“Loses count?” I asked.
“Yes,” my father admitted, “that sometimes happens. But it’s not a problem. You just make seven rights, and you’re okay again.”
I couldn’t resist. ”Do you ever go for 11?” I asked.
“No,” he said ” If we miss it at seven, we just come home and call it a bad day. Besides, nothing in life is so important it can’t be put off another day or another week.”
My mother was never in an accident, but one evening she handed me her car keys and said she had decided to quit driving.. That was in 1999, when she was 90.
She lived four more years, until 2003. My father died the next year, at 102.
They both died in the bungalow they had moved into in 1937 and bought a few years later for $3,000. (Sixty years later, my brother and I paid $8,000 to have a shower put in the tiny bathroom — the house had never had one. My father would have died then and there if he knew the shower cost nearly three times what he paid for the house.)
He continued to walk daily — he had me get him a treadmill when he was 101 because he was afraid he’d fall on the icy sidewalks but wanted to keep exercising — and he was of sound mind and sound body until the moment he died.
One September afternoon in 2004, he and my son went with me when I had to give a talk in a neighboring town, and it was clear to all three of us that he was wearing out, though we had the usual wide-ranging conversation about politics and newspapers and things in the news.
A few weeks earlier, he had told my son, “You know, Mike, the first hundred years are a lot easier than the second hundred.” At one point in our drive that Saturday, he said, “You know, I’m probably not going to live much longer.”
“You’re probably right,” I said.
“Why would you say that?” He countered, somewhat irritated.
“Because you’re 102 years old,” I said..
“Yes,” he said, “you’re right.” He stayed in bed all the next day.
That night, I suggested to my son and daughter that we sit up with him through the night.
He appreciated it, he said, though at one point, apparently seeing us look gloomy, he said: “I would like to make an announcement. No one in this room is dead yet”
An hour or so later, he spoke his last words: “I want you to know,” he said, clearly and lucidly, “that I am in no pain. I am very comfortable. And I have had as happy a life as anyone on this earth could ever have.”
A short time later, he died.
I miss him a lot, and I think about him a lot I’ve wondered now and then how it was that my family and I were so lucky that he lived so long.
I can’t figure out if it was because he walked through life, or because he quit taking left turns.
Life is too short to wake up with regrets.
So love the people who treat you right. Forget about the one’s who don’t. Believe everything happens for a reason. If you get a chance, take it & if it changes your life, let it. Nobody said life would be easy, they just promised it would most likely be worth it.
GENEVA - Most of the 2.6 million deaths of young people each year are preventable, according to a new study supported by the World Health Organization and released in Geneva Friday.
The main causes of deaths in the 10-24 age group were road traffic accidents, complications during pregnancy and child birth, suicide, violence, HIV/AIDS and tuberculosis.
The study, to be published in the Lancet, a medical journal, found that 97 percent of these deaths were taking place in low and middle-income countries.
“Young people … often fall through the cracks,” said Daisy Mafubelu, WHO’s expert for family and community health.
She said it was important to improve their access to information and services “and help young people avoid risky behaviors that can lead to death”.
There are an estimated 1.8 billion people that fall into this age group, accounting for 30 percent of the world’s population.
Road traffic accidents could be avoided through more appropriate speed limits, strict enforcement of drunk-driving laws and by the use of helmets and safety belts, the WHO said.
Moreover, young people need sex education, condoms and other contraceptives, the ability to perform safe abortions, access to antenatal and obstetric services and testing and care for HIV/AIDS.
The study also led the researchers to conclude that suicide and other violence could be prevented through life-skills training and positive parental involvement in young people’s lives.
Furthermore, the WHO recommended that access to lethal means of all kinds, including guns and toxins, should be reduced, along with limiting the consumption of alcohol.
There also needed to be better care and support for those exposed to child abuse, youth violence, and sexual assault, to help young people deal with the immediate and long-term consequences of these traumatic events.
Exact cause of a leg cramp is extremely difficult to pinpoint
The exact cause of a leg cramp is extremely difficult to pinpoint, some of the factors leading to the same are as follows -
Muscle fatigue due to overexertion
Rigorous exercises
Dehydration
Excess weight
Electrolyte, hormonal or fluid imbalances
Side effects of certain medicines such as diuretics.
An unusual or a different exercise than what is done normally.
Diminished blood supply.
Nerve abnormalities.
Nerve and muscle diseases.
Massaging the muscle
What to do when you get a leg cramp?
Stretch the sore muscle, follow your instinct, your body will automatically guide you in the correct manner.
Massage the cramped muscle gently in the natural direction of the muscle. This helps relax the contraction and ease the pain.
A hot shower or warm bath is a good way to relax the muscle.
Use cold packs on the affected muscle. This relaxes the tensed muscles.
For a cramped calf muscle, stretch and massage the leg by straightening it and pointing the toes upward, towards the head.
Use a warm towel or heating pad to alleviate pain or tenderness following a cramp.
Diet rich in potassium and calcium
Increase water consumption to stay well hydrated throughout the day.
Potassium and calcium rich foods will keep the level of these two much required nutrients at optimum levels preventing cramping episodes.
Stay hydrated during work
Some preventive measures -
Dehydration causes leg cramps. It is especially important to stay well hydrated during workouts.
Drink plenty of fluids before, during and after exercising.
Stretching prior to starting your exercise routine is extremely important.
Stretches help relax muscles and thus prevent leg cramps.
When beginning a workout regime, it is imperative that you do so gradually. A sudden increase or changes in physical activity levels can cause leg cramps. Keep rolled up bed sheets or blankets at your feet to prevent your toes and feet from pointing downward while you are asleep. Riding a stationary bicycle for a few minutes before bedtime could prevent cramps from developing during the night.
DETROIT - Michigan researchers have developed a powerful new GPS-like tool to identify proteins that are affected by a chemical process that is key to aging and disease development.
The probe, which works like a GPS or navigation system for finding these proteins in cells, could lead to new insights into disease processes and identify new targets for disease treatments, according to the researchers.
KateCarroll and colleagues said that it has long been known that the excess build-up of highly reactive oxygen-containing molecules in cells can contribute to aging, and possibly to disorders like cancer and Alzheimer’s disease.
It is believed that a diet rich in antioxidants, which are abundant in fruits and vegetables, may help cease this cell-damaging process by blocking the accumulation of these molecules, also known as reactive oxygen species (ROS).
However, to date, scientists have not found any proper tools to study the effects of these molecules in detail.
Thus, the researchers developed a new molecule called DAz-2, which, according to them, functions like a tiny GPS device for quickly finding specific proteins that are affected by ROS.
The molecules do this by chemically “tagging” sulfenic acid, which is formed in cells and indicates that a protein has undergone a type of reaction - called oxidation - caused by ROS.
In lab studies using cultured cells, the scientists identified more than 190 proteins that undergo this reaction.
The researchers said that the study could lead to better strategies for fighting the wide range of diseases that involve these excessive oxidation reactions.
The study will be published in ACS Chemical Biology, a monthly journal
YAOUNDE - Gorillas carry the parasite that causes malignant malaria in humans, a finding that could help in efforts to develop a vaccine for malaria, researchers say.
Malaria is a sometimes fatal disease, usually contracted from mosquitoes, most commonly in areas such as sub-Saharan Africa and South Asia. People who contract malaria typically develop flu-like symptoms with high fevers and chills, according to the U.S. Centers for Disease Control and Prevention.
In the new study, researchers analyzed fecal samples from 84 gorillas in Cameroon and blood samples from three gorillas in Gabon and found the parasite Plasmodium falciparum, which was previously believed to only infect humans. P. falciparum causes 85 percent of malignant malaria infections in humans and nearly all deaths from malaria.
The scientists also found that the gorillas carried two closely related species of malaria parasites: Plasmodium GorA and Plasmodium GorB.
The discovery of P. falciparum in gorillas complicates efforts to eradicate malaria, according to the study published in this week’s issue of the Proceedings of the National Academy of Sciences.
“Hundreds of billions of dollars are spent each year toward ridding humans of malignant malaria. But success may be a pyrrhic victory, because we could be re-infected by gorillas — just as we were originally infected by chimps a few thousand years ago,” study co-author Francisco Ayala, a biologist at the University of California, Irvine, said in a university news release.
Along with potentially aiding in the development of a malaria vaccine, this finding helps improve understanding of how infectious diseases such as HIV, SARS and bird and swine flu can be transmitted from animals to humans, the researchers noted.
Each year, malaria sickens about 500 million people worldwide and causes 2 million infant deaths. Four kinds of malaria parasites can infect humans: P. falciparum, P. vivax, P. ovale, P. malariae. Infection with P. falciparum, if not promptly treated, may lead to death, according to the CDC.
WASHINGTON - A Northeastern University neurobiologist is collaborating with Harvard University researchers to develop micro flying robots that will emulate the bees’ brain, body and collective behavior.
Biology professor JosephAyers would create robots, called the robobees, which would mimic the communal feeding behavior of bee colonies.
The project will draw on the knowledge of computer scientists, engineers, and biologists to construct an electronic nervous system, a supervisory architecture and a high-energy source to power the innovative robots.
“This project will integrate the efforts and expertise of a diverse team of investigators to create a system that far transcends the sum of its parts. We expect substantial advances in basic science at the intersection of these seemingly disparate disciplines to result from this effort,” said Ayers.
Inspired by the biology of the bee and the insect’s colonial behaviour, the project aims to advance miniature robotics and the design of compact high-energy power sources.
The project would also spur innovations in ultra-low-power computing and electronic “smart” sensors that mediate biomimetic control.
In addition, it would refine coordination algorithms to manage multiple, independent machines.
Ayers is widely known for his work in biomimetics- the science of adapting the control systems found in nature to inform design of engineered systems to solve real-world problems-including the development of RoboLobster and RoboLamprey.
The autonomous, biomimetic underwater robotic models emulate the operations of the animals’ nervous systems using an electronic controller based on nonlinear, moving models of neurons and synapses.
“Animals have evolved to occupy every environmental niche where we would hope to operate robots, save outer space. They provide proven solutions to problems that confound even the most sophisticated robots, and our challenge is to capture these performance advantages in engineered devices,” said Ayers.
ATLANTA - Researchers at Georgia State University have thrown light on how pain in infancy alters the brain’s ability to process pain in adulthood.
The study has now indicated that infants who spent time in the neonatal intensive care unit (NICU) show altered pain sensitivity in adolescence.
The results have profound implications, and highlight the need for pre-emptive and post-operative pain medicine for newborn infants.
The study sheds light on how the mechanisms of pain are altered after infant injury in a region of the brain called the periaqueductal gray, which is involved in the perception of pain.
For the study, graduate student JamieLaPrairie and professor AnneMurphy used Sprague-Dawley rats to examine why the brief experience of pain at the time of birth permanently decreased pain sensitivity in adulthood.
Endogenous opioid peptides, such as beta-endorphin and enkephalin, function to inhibit pain and they are also the ‘feel good’ substances that are released following high levels of exercise or love.
As these peptides are released following injury and act like morphine to dampen the experience of pain, the researchers tested to see if the rats, who were injured at birth, had unusually high levels of endogenous opioids in adulthood.
Thus, they gave adult animals that were injured at the time of birth a drug called naloxone, which blocks the actions of endogenous opioids.
The researchers observed that after animals received an injection of naloxone, they behaved just like an uninjured animal.
Using a variety of anatomical techniques, the investigators showed that animals that were injured at birth had endogenous opioid levels that were two times higher than normal.
Interestingly, while there is an increase in endorphin and enkephalin proteins in adults, there is also a big decrease in the availability of mu and delta opioid receptors, which are necessary in order for pain medications, such as morphine, to work.
This means that it takes more pain-relieving medications in order to provide relief as there are fewer available receptors in the brain. Studies in humans are reporting the same phenomenon.
The number of invasive procedures an infant experienced in the NICU is negatively correlated with how responsive the child is to morphine later in life.
Thus, the researchers concluded that the more painful procedures an infant experienced, the less effective morphine is in alleviating pain.
The study has been published online in the journal Frontiers in Behavioral Neuroscience.
The Pill Bottle Gets a Cell Phone, to Remind You to Take Your Medicine
CAMBRIDGE - “Hi! This is your aspirin bottle calling. I haven’t seen you in a while. Why don’t you come see me soon? I’m good for the heart, you know.”
That’s the spirit, if not the wording, of the calls that will come from new pill bottle caps that connect to AT&T Inc.’s wireless network.
A Cambridge, Mass.-based startup called Vitality Inc. was set to announce the pill-bottle system Thursday, saying it helps solve one of the biggest problems in medicine: that people don’t consistently take the drugs they’re prescribed.
That costs the U.S. $290 billion in added medical spending each year, according to a study published in August by the New England Healthcare Institute. Mortality rates are twice as high among diabetes and heart disease patients who don’t take their pills properly, it said.
With Vitality’s system, when a pill-bottle cap is opened, it uses a close-range wireless signal to tell a base station in the home. That station, which looks like a night light, essentially has a cell phone inside that can send messages through AT&T’s network.
If the bottle isn’t opened at the appointed time, the cap and night light start blinking to remind the owner to take the medication. If that doesn’t serve as enough of a hint, they start playing jingles as well. If the bottle stays unopened, the night light will send a message to Vitality’s system, which can then place an automated phone call or send a text message with a reminder.
That points to another possibility opened by the wireless bottle cap: making the pill-taking routine more than just a matter between the patient and the bottle. Vitality’s system can be set to alert a relative if someone isn’t taking medicine.
“The social aspect of this is important,” Vitality CEO DavidRose said. “Almost every successful behavior change program, the academics will tell you, involves social dynamics, whether it’s smoking cessation or Weight Watchers.”
A price for the new system hasn’t been disclosed. Vitality hopes insurance and drug companies will get on board with the system and cover the cost.
Vitality has been selling an earlier version of the product in small numbers from its Web site for $99. In that version, the night light doesn’t contain a cell phone. Instead it connects to a third piece of hardware, a “gateway” plugged into a home’s Internet router. But not all homes have routers, and configuring them can be tricky. The AT&T-powered night light simplifies the installation.
BEVERLY HILLS – US Tele-Medicine, the operators of this blog, rarely recommends any product because there are always opposing viewpoints with respect to ingredients, integrity or manufacture.There are no perfect products manufactured by man.There are close exception to that understanding.This is one of them.
Wheat is a mainstay of many peoples and national diets around the world.Wheat itself is quite healthy and beneficial source of carbs and fibers.Wheat becomes less healthywhen we add yeasts, preservatives, enhancers and flavors, in any baked goods.This is not to mention the sugars, syrups, fruits, emulsifiers and binders, added to the wheat by most mass- market commercial bakeries.This is when wheat becomes toxic.
All commercial brands of breads have some other “natural” product added to the wheat, which always disturbs the structure of the beneficial fibers and confuses the body looking for clean carbs.Except one.
In our opinion, the BEST commercial bread is found at Trader Joe’s Markets and branded as “Pain Pascal Organic Demi Miche.” The ingredients: Organic Whole Wheat Flour, Filtered Water, and Sea Salt.
The texture is incredibly soft, dense like a European country bread and very moist.The taste is superb and especially aromatic lathered with some good Irish or Danish butter.It toasts very heartily and the full crispy-on-the-outside, moist- on- the- inside effect is always there.
It is delicious, hearty, attractive, and very healthy for you to eat.Bon appetite.
SYDNEY - A new online survey has found that women are happier than men, and that young people are more likely to be distressed.
The survey of 309 people, conducted by the Mental Health Association NSW (MHA), also found that spending time with friends or being a member of a club contributed much to an individual’s happiness.
It also showed that those unsure whether they would like socialising, “fence sitters”, were more prone to mental ill-health.
A majority of women reported feeling happier than men, and they also had more active social lives.
“The report reveals that there is a strong link between participating and feeling happy when socialising with friends or being a member of a club,” the Sydney Morning Herald quoted MHA spokeswoman Nataly Bovopoulos as saying in a statement.
“It was also interesting to note that the majority (72 per cent) of the respondents were female, which indicates immediately that women are more likely to get involved than men,” she added.
Those who were experiencing a disadvantage from factors such as a financial crisis reported being distressed, as did 18 to 25-year-olds, who were unhappier than older age groups.
The survey, which asks people if they attend religious services or use social networking sites such as Facebook, is part of research into community participation, psychological distress, and mental well-being trends in NSW.
Bovopoulos also said it was possible for people to feel unhappy without being depressed or anxious, however, most people who were distressed reported feeling unhappy.
NEW YORK - Researchers at the NYU School of Medicine say that they have gained significant insights into a mechanism that plays an important role in making human pathogens like Staphylococcus aureus and Bacillus anthracis resistant to numerous antibiotics.
Writing about their work in the journal Science, they have said that their study provides evidence that Nitric Oxide (NO) is able to alleviate the oxidative stress in bacteria caused by many antibiotics, and that it also helps to neutralize many antibacterial compounds.
Lead researcher Evgeny A. Nudler, The Julie Wilson Anderson Professor of Biochemistry at NYU Langone Medical Center, says in the report that eliminating this NO-mediated bacterial defence renders existing antibiotics more potent at lower, less toxic, doses. he researcher further says that the study’s findings pave the way for new ways of combating bacteria that have become antibiotic resistant.
A study Nudler led a few years ago had shown that bacteria mobilize NO to defend against the oxidative stress.
The new study supports the radical idea that many antibiotics cause the oxidative stress in bacteria, often resulting in their death, whereas NO counters this effect.
Based on this work, the researchers have come to the conclusion that scientists may use commercially available inhibitors of NO-synthase, an enzyme producing NO in bacteria and humans, to make antibiotic resistant bacteria like MRSA and ANTHRAX more sensitive to available drugs during acute infection.
“Developing new medications to fight antibiotic resistant bacteria like MRSA is a huge hurdle, associated with great cost and countless safety issues. Here, we have a short cut, where we don’t have to invent new antibiotics. Instead, we can enhance the activity of well established ones, making them more effective at lower doses,” says Nudler.
“We are very excited about the potential impact of this research in terms of continuing to push the boundaries of research in the area of infectious diseases,” said Dr. Vivian S. Lee, vice dean for science, senior vice president and chief scientific officer of NYU Langone Medical Center.
“With the emergence of drug resistant bacteria, it’s imperative that researchers strive to find conceptually new approaches to fight these pathogens,” Lee added.
GENEVA - India, Nigeria and Congo account for 40 percent of the 8.8 million deaths of children under the age of five years, a new Unicef study released Friday says.
Though a little satisfied over a drop in child mortality, the UN agency said these three countries were a key to the world achieving the millennium development goals by 2015. The goals have been set up by United Nations.
“A handful of countries with large populations bear a disproportionate burden of under-five deaths, with forty per cent of the worlds under-five deaths occurring in just three countries: India, Nigeria and the Democratic Republic of Congo, the global report said.
Unless mortality in these countries is significantly reduced, the MDG (millennium development goals) targets will not be met, said Unicef Executive Director AnnM.Veneman.
The study said achieving the goal of a two-thirds reduction in the under-five mortality rate by 2015 would require a strong sense of urgency with targeted resources for greater progress.
While praising some countries for making efforts in reducing the mortality, Unicef expressed dissatisfaction that South Africa was not doing enough in this regard.
In some countries, the progress is slow or non-existent. In South Africa, the under-five mortality rate has actually gone up since 1990. The health of the child is inextricably linked to the health of the mother and South Africa has the highest number of women living with HIV in the world, the report said.
Recent commitments by the government to scale up interventions to prevent mother-to-child transmission of HIV/AIDS should help improve the situation, the UN agency hoped.
Unicef said the progress could be accelerated even in the poorest environments, through integrated, evidence-driven, community-based health programmes that focus on addressing the major causes of death — pneumonia, diarrhoea, newborn disorders, malaria, HIV and under-nutrition.
The two leading causes of under-five mortality are pneumonia and diarrhoea. New tools, such as vaccines against pneumococcal pneumonia and rotaviral diarrhoea, could provide (the) additional momentum, the report said.
The data, however, shows a 28 per cent decline in the under-five mortality rate, from 90 deaths per 1000 live births in 1990, to 65 deaths per 1000 live births in 2008 in the world.
According to these estimates, the absolute number of child deaths in 2008 declined to an estimated 8.8 million from 12.5 million in 1990, the base line year for the millennium development goals.
Compared to 1990, 10,000 fewer children are dying every day. While progress is being made, it is unacceptable that each year 8.8 million children die before their fifth birthday, added Veneman.
White willow bark is a tree native to Europe and Asia. The name “white willow” comes from the color of the leaves, which are covered with fine white hairs.
The use of white willow bark medicinally goes far back. Ancient Egyptians used white willow for inflammation. The Greek physician Hippocrates wrote about white willow’s medicinal uses in 5th century B.C.
In 1829, scientists in Europe identified what was believed to be the active ingredient in white willow bark—a compound called salicin. Public demand grew rapidly.
Extracting salicin from herbs was considered to be expensive and time-consuming, so a synthetic salicylic acid version was developed in Germany in 1852 and quickly became the treatment of choice (salicin is converted in the body to salicylic acid).
The problem was that it was harder on the stomach. At therapeutic doses, people using the synthetic salicyclic acid developed stomach ulcers and bleeding.
The German company Bayer eventually created a synthetic, less harsh derivative of salicylic acid, called acetylsalicylic acid (ASA), and mass-produced it under the name aspirin. Despite this, aspirin is still known for irritating the stomach lining.
Why do people use white willow bark?
White willow bark is used for conditions that cause pain, inflammation, or fever, such as:
* Acute back pain
* Fever
* Flu
* Joint pain
* Osteoarthritis
* Pain
People take white willow bark instead of aspirin because it does not appear to be as irritating to the stomach lining. It may be because the salicin found naturally in white willow bark is only converted to the acid form after it is absorbed by the stomach.
Researchers have also suggested that white willow bark is more effective than aspirin because of other active compounds that are found in the bark but not the drug. Animal research at Cairo University compared a willow bark extract to ASA and found that a willow bark extract was as effective as aspirin in reducing inflammation, even though the salicin content was lower than an equivalent dose of ASA.
What research has been done on white willow bark?
* In a German study, the effectiveness of a willow bark extract providing 240 mg of salicin a day was compared to placebo in a 2-week randomized controlled trial in 78 people with osteoarthritis. After two weeks, the willow bark patients’ pain scores were reduced by 14% compared to the placebo group, which had a 2% increase in pain scores.
* A randomized controlled trial published in the American Journal of Medicine examined the use of 120 mg or 240 mg salicin or placebo in 210 patients with an low back pain. In the fourth and final week of the study, 39% of the group taking 240 mg salicin were pain-free for at least 5 days, compared to 21% in the 120 mg group and only 6% in the placebo group.
* Two randomized controlled 6-week trials investigated the effectiveness and safety of willow bark in 127 patients with hip and/or knee osteoarthritis and 26 patients with rheumatoid arthritis. In the osteoarthritis trial, patients received either willow bark providing 240 mg of salicin a day, 100 mg a day of the drug diclofenac, or a placebo. Patients in the rheumatoid arthritis trial received either willow bark or a placebo. The results found that the drug diclofenac was more effective than placebo in osteoarthritis patients but white willow bark was not. In rheumatoid arthritis patients, willow bark wasn’t found to be more effective than placebo.
Common Doses
Studies have used white willow bark extracts that provide 120 mg to 240 mg of salicin per day.
Safety
Because white willow bark contains salicylates, the same precautions as aspirin should be taken until research has shown otherwise. The following people should not take white willow bark:
* People with an aspirin allergy or sensitivity. There has been a published report of a 25 year old woman who was admitted to emergency with anaphylaxis after taking 2 capsules of a weight loss supplement that contained willow bark. The patient had a history of allergy to acetylsalicylic acid. No other possible causes for anaphylaxis were identified in that patient.
* People with peptic ulcer disease or kidney disease.
* The herbs ginkgo, vitamin E, and garlic may increase the risk of bleeding if combined with white willow.
* People with hyperuricemia, gout, and asthma.
* Children and teenagers, especially with flu-like symptoms, chicken pox, or Reye’s syndrome.
* Pregnant or nursing women.
White willow bark should be avoided two weeks before or after surgery.
Side effects
There have been few reported side effects. However, the same side effects as aspirin may theoretically occur, especially at higher doses: ringing in the ears, ulcers, stomach burning, pain, cramping, nausea, gastrointestinal bleeding and liver toxicity, rash, dizziness, and kidney impairment.