Scientists Create Super-Strong Collagen

Scientists Create Super-Strong Collagen

MADISON A team of University of Wisconsin-Madison researchers has created the strongest form of collagen known to science, a stable alternative to human collagen that could one day be used to treat arthritis and other conditions that result from collagen defects.

“It’s by far the most stable collagen ever made,” says Ron Raines, a University of Wisconsin-Madison professor of chemistry and biochemistry who led the study, published in the Jan. 12 issue of the Proceedings of the National Academy of Sciences.

Collagen is the most abundant protein in the human body, forming strong sheets and cables that support the structure of skin, internal organs, cartilage and bones, as well as all the connective tissue in between. For decades, doctors have used collagen from cows to treat serious burns and other wounds in humans despite the risk of tissue rejection associated with cross-species transplants.

In 2006, Raines’ team d out how to make human collagen in the lab, creating collagen molecules longer than any found in nature. Now, with funding from the National Institutes of Health, the researchers have taken this line of inquiry one step further, creating a form of super-strong collagen that may one day help millions. Raines says this artificial collagen holds promise as a therapy for conditions such as arthritis, which is caused by a breakdown of the body’s natural collagen and affects more than 46 million Americans.

To make the new form of collagen, Raines’ team substituted two-thirds of the protein’s regular amino acids with less-flexible versions that stiffened the overall structure of the protein and helped it hold its form. “The breakthrough of this approach was the use of rigid analogues that have shapes similar to [the shapes the natural amino acids take] in the folded, functional form of the protein,” explains Raines.

The resulting collagen holds together at temperatures far above what it takes for natural collagen to fall apart. And although it’s built largely from amino acids that aren’t found in nature, X-ray crystallography confirms that the three-dimensional structure of the lab-made collagen is indistinguishable from that of natural collagen, according to UW-Madison bacteriologist Katrina Forest, a co-author of the study.

“This hyper-stable collagen is really a testament to the power of modern protein chemistry,” says Raines.

109 thoughts on “Scientists Create Super-Strong Collagen

  1. I think I’ve discovered the secret of life – you just hang around until you get used to it.

  2. I have actually been trying to get in touch with you but I can’t seem to find the correct e-mail address …..

  3. Kudos for this amazing posting, I will attach this web site to my rss feeds, a friend just told me in regards to this last week. this may be the greatest…

  4. That is some inspirational stuff. Never knew that opinions could be this varied. Thanks for all the enthusiasm to offer such helpful information here.

  5. This site seems to recieve a large ammount of visitors. How do you advertise it? It gives a nice individual twist on things. I guess having something real or substantial to give info on is the most important factor.

  6. I’m not very as well familiar with this subject. I additional so just prefer to stop by blogs for layout tips and factors like that. But you in actual fact constructed a subest that i usually care practically nothing about rather intriguing. It is a magnificent blog to design mine immediately after. I wish you do not thoughts if i bookmark your webpage, in order that i can effortlessly search it again by the long term. Cheers

  7. This is my first time here. I found so much interesting stuff in your weblog particularly it’s discussion. From the tons of comments on your articles, I guess I’m not the only one having a good time right here!

  8. Hello – I should say, I sure am happy with your site. I had no difficulty navigating via all the tabs and the information was really easy to access. I found what I required in no time at all. Truly awesome.

  9. I was just examining this page it’s very well written, My organization is looking around on the internet searching for the correct way to do this blog thing and your blog definitely is extremely impressive.

  10. I just added your web site to my blog roll, I pray you’ll give some thought to doing the same.

  11. I have pimples as well. It takes a lot of effort to treat it. Thank you for the information presented in this blog post.Many people could have cured their acne but they gave up,,.

  12. Greetings, found your website by pure accident this afternoon, but am very pleased that I have! Not only informative but it’s also easy to understand unlike many that I come across!! (The site I’m trying to work on, is related to neck pain relief). I have been looking to see if I could work out what layout you had implemented, anyone have anny ideas? My site is a review site for neck pain relief. I’m trying the same look on my website, which is related to neck pain relief, – but I find for some reason it appears to reload quicker on yours even though you appear to have a fair bit more material. Have you used any widgets that have increased speed? : Sorry to go on, but lastly to say, I value such a great website and it’s a wonderful model for my humble overview website of neck pain relief. I’ll be looking to improve my own site. I’ll visit your impressive blog as often as I can.

  13. Hi, I’m a college English student and I’m learning a lot about writing by viewing blogs. I really enjoy your style of writing. It’s easy to understand but with great details. Your vocabulary makes it fun to read and absorb. That’s a huge part of writing. Your readers have to be able to understand what you’re saying and the publication has to be engaging. You need to engage your readers, so they will come back again. You do a good job with all of these aspects. Thanks!

  14. US Tele-Medicine Blog » Blog Archive » Scientists Create Super-Strong Collagen is a pretty good post. I simply stumbled upon your blog and wanted to say that I have actually loved reading your blog articles. Any way I’ll be getting your feed and I hope you post once more soon.

  15. Does anyone know if there is any truth to the rumor that someone in Sam Walton’s family (Wal-Mart) owns Lowe’s. I was told it is his brother-in-law or someone without the same last name. Does anyone know for sure?

  16. This is something I have to do more research into, thank you for the post.

  17. Thanks for posting this kind of a terrific site. this weblog was not just knowledgeable but also very inventive too. There typically are a restricted number of writers who can produce technical information that creatively. we search for articles about a subject such as this. I’ve gone in detail through many web sites to find knowledge regarding this.Maintain composing in !!

  18. Thanks for taking the time to discuss this, I feel strongly about it and love learning more on this topic. If possible, as you gain expertise, would you mind updating your blog with extra information? It is extremely useful for me.

  19. Hi to all, came across your website by pure chance in the early hours, but am very pleased that I did! As well as being full of infomation and also easy to read as opposed to many that I find. (My site, is a review of hypnotherapy downloads). I have been trying to work out what layout you had implemented, anyone have an idea? The site I’m making is a review site for hypnotherapy downloads. I employ a similar layout on my website, which is related to hypnotherapy downloads, – I’ve found for whatever reason it appears to load swifter here, even though here you appear to have even more entries. Have you used any software that have increased speed? — Anyway, I appreciate such a great site and it’s a wonderful inspiration for my review site of hypnotherapy downloads. I hope I can enhance my own blog attempt. Obviously, I’ll check out this brilliant site often.

  20. Strange this post is totaly unrelated to what I was searching google for, but it was listed on the first page. I guess your doing something right if Google likes you enough to put you on the first page of a non related search. 🙂

  21. Hi there! I found your site accidentally this evening, but am really pleased that I did! Not only is it significant, but also straightforward to use as opposed to scores that I’ve found! I was trying to discover what theme you had employed, – anybody have any thoughts? I’ve utilised a comparable primary design and style myself, but find that your web site loads far more rapidly, though you seem to have a great deal a lot more material. The only problem I’ve had is with the header, which seems narrower that the actual page in Opera v8.0, although it seems OK in IE and in firefox… maybe it’s time to change! Fantastic web site, very tidy job, and a great inspiration for my humble attempt! I’ll be looking to enhance my own website and will certainly stop by again soon!

  22. Your feeds are fed into other blogger’s RSS feeders, making it syndicated or putting in another way, people out there will subscribe to them and receive online copies of your text.

  23. Thanks for taking the time to share this, I feel strongly about it and love reading more on this topic. If possible, as you gain knowledge, would you mind updating your blog with more information? It is extremely helpful for me.

  24. There are certainly a lot of details like that to take into consideration. That?s a great point to bring up. I offer the thoughts above as general inspiration but clearly there are questions like the one you bring up where the most important thing will be

  25. Phlebotomy Certification Previously noticed of phlebotomy certification? Greater nevertheless, previously noticed of phlebotomy? Indeed, it isn’t a typical phrase you hear close to. In case, you will be wondering what it is, phlebotomy is usually a method by way of which blood is removed by signifies of a needle. You may well be pondering, are not these people termed nurses? Properly, no. Nurses can execute phlebotomy but not all phlebotomists are nurses. People today who’re qualified only to remove blood that has a needle are termed phlebotomists, they too work in hospitals and clinics but that is every one of the health-related help they are able to produce unless of course they’re prepared for more.

  26. I stumbled upon your blog and it’s splendid for my situation. It includes marvelous and useful articles. I read just about all of them and got so much from them. If you ask me, you are doing an outstanding work. Keep on! I would like to say thanks to you for making such a great web site.

  27. Hi Webmaster, commenters and everybody else !!! The blog was absolutely fantastic! Lots of great information and inspiration, both of which we all need!Keep ’em coming… you all do such a great job at such Concepts… can’t tell you how much I, for one appreciate all you do!

  28. Long but a splendid info buddy. Thanks for sharing! However I’m having issue with your RSS . Unable to subscribe to it. So anybody facing identical RSS feed problem? Anybody who knows kindly reply. Thanks in advance

  29. Hi Angele. I don’t see any sense, because Munsch has explaned everything in details. Please look at the last comments!

  30. I recently came across your web site and have been reading along. I thought I would leave my very first comment. Nice blog. I will keep visiting this website very frequently.

  31. I do not comprehend the reason why folks disagree with this. The idea makes perfect sense the moment you read through the complete posting.

  32. This really is truly good content and educational weblog, I adore what you’ve carried out here, along with sharing great stuff with great ideas and concepts, I’m truly pleased to submit my comment on this weblog, many thank you’s to the author.

  33. I can see that you are an expert in this area. I am starting a website soon, and your information will be very useful for me.. Thanks for all your help and wishing you all the success in your business.

  34. Where can I download normal theme for WP? There are very nice themes, but sometimes complicated in settings. I tried last versions of Designora, Press 88, Secret Garden 2, DesignPile, also I installed also BlueSense – simple, but optimized for adsense. Rarely we can see something normal but good in settings.

  35. Many thanks very much for that information. I’ve been searching for this for a while with Bing and it has been a real task.

  36. genuinely a exceptional posting. I will undoubtedly be reading this blog a lot more.

  37. I’m not really the type of person that leaves behind a comment on blogs and forums but this is without question an intriguing story. I am still thinking just what the point is however allow me some time and I will know.

  38. I could see that you’re an expert in your field! I’m launching a brand new web page quickly and hey these information will be really useful for me man. Thanks for the assist and I wish you results! =))

  39. We were doing a search and came across this site. Have to say that this info is on point! Keep writing more. I will be reading your articles

  40. I was actually searching to purchase an ecig. Before I order electronic cigartette will you do an article on how it works

  41. Looking good is difficult. It is amazing on what people will do to reach their goals. It’s not for me to judge.

  42. Just after looking at this a number of questions came about. I am going to think it over before submitting these below simply because I do not want to worry you with anything I could have simply look for in Bing and yahoo.

  43. Hi I found your site by mistake when i was searching yahoo for this acne issue, I must say your site is really helpful I also love the design, its amazing!. I don’t have the time at the moment to fully read your site but I have bookmarked it and also add your RSS feeds. I will be back in a day or two. thanks for a great site.

  44. This is an amazing blog post. Thank you very much for the excellent post provided! I was looking for this article for quite some time, but I was not able to find a trusted website.

  45. Thank you for providing great post about the subject. I’m a fan of your website. Keep up the great work.

  46. I’ll stick a link to this website on my site. I’m certain my visitors will think of this article very useful.

  47. Really interesting post to read on.. I am really impressed with this post. Looking for future posts.

  48. I’ll post a link to this website on my website. I am certain my visitors will think of this post really informative.

  49. Thanks for this great website. I am trying to read some more posts but I cant get your website to display properly in my Opera Browser. Thanks again.

  50. Be glad of life because it gives you the chance to love, to work, to play, and to look up at the stars.

  51. I believe the information outlined in the post is awesome. I’ve been participating in some homework on the subject matter and your writings truly answered many concerns I had. I’m doing an essay and school assignment for my English class and currently checking out many information sites to review.

  52. Thanks for providing valuable information about the topic. I am an admirer of your site. Keep up the good job.

  53. I’m happy to have found your very good article! I agree with some of your readers and will eagerly look forward to your coming updates. Just saying thanks will not just be adequate, for the wonderful lucidity in your writing. I will instantly grab your rss feed to stay privy of any updates. Good work and much success in your business efforts.

  54. I admire the great article you provide in your entries. I’ll bookmark your page and have my children visit here often. I am very sure they will learn lots of new articles in your site than anybody else!

  55. It’s hard for me to read through your blog post because there are problematic images all over the web page.

  56. I will post a link to this website on my page. I’m sure my readers will think of this article very useful.

  57. I’ll post a link to this blog on my blog. I am certain my readers will find this article really useful.

  58. awesome article 😀 looking forward to seeing more posts 🙂

  59. Pingback: Plump it up!: The Purpose of Collagen Injections | A Womans Life

  60. Pingback: US Tele-Medicine Blog » Blog Archive » Scientists Create Super … | Drakz blog Online Service

  61. Pingback: US Tele-Medicine Blog » Blog Archive » Scientists Create Super … | protein-power-lifeplan | protein-power-lifeplan needs supplementing

Leave a Reply

Your email address will not be published.