WILMINGTON – Based on more than 50 experiments with mice, scientists have mapped out the basic steps taken by a particular set of white blood cells in setting the pace for recovery after serious lung injury.
The white blood cells are called regulatory T-cells, or Tregs for short, and their best known function is to keep the body’s immune system from attacking its own healthy tissues.
“Our study results are the critical first leads in finding treatments for a clinical condition that until now has had none, despite its high mortality,” says study senior investigator Landon King, Johns Hopkins University.
“When a patient develops acute lung injury, we want the critical care medicine team to be able to do more than just stabilize the patient on a ventilator,” said
Some 200,000 Americans suffer some form of sudden, acute lung injury (
Among them are people with severe acute respiratory distress syndrome caused by infection, the most severe form of
Almost all people with
The study was published online in the Journal of Clinical Investigation.