The gene-editing of DNA inside living cells is considered by many to be the preeminent technological breakthrough of the new millennium. Researchers in medicine and agriculture have rapidly adopted it as a technique for discovering cell and organism functions. But its commercial prospects are much more complicated. Continue reading
NEW YORK – An innovative drug delivery system comprising nanoparticles quickens response in erectile dysfunction (
“The response time…was… just a few minutes, which is basically what people want in an
“In both rats and humans, it can take 30 minutes to one hour for oral
Besides, “an estimated 30 to 50 percent of men with
The new system, after successful testing in rats, could potentially prevent side-effects associated with oral
The drug-delivery system, developed by Einstein College scientists, can carry tiny payloads of various drugs or other medically useful substances and release them in a controlled and sustained manner.
That could spell safer and more effective
Tens of millions of men worldwide have benefited from oral
However, these medications – which belong to PDE5 inhibitors – have limitations. They can cause systemic and serious side-effects.
They include headache, facial flushing, nasal congestion, upset stomach, abnormal vision as well as isolated reports of hearing and vision loss.
Men who have recently suffered a heart attack or stroke or have severe heart disease should use these drugs with caution or not at all.
This study was done to evaluate whether the nanoparticles, which have been shown to penetrate the skin, might allow the targeted delivery of compounds that treat
“Most of the animals, nearly 90 percent, showed a response to treatment with the nanoparticles,” says co-author Joel M.
Clinical studies on humans could begin in a few years if animal studies continue to show that the nanoparticle delivery system is safe and effective, says a college release.
The study was published in the online edition of the Journal of Sexual Medicine.