Erasing the Signs of Aging in Cells is Now a Reality

Inserm’s AVENIR “Genomic plasticity and aging” team, directed by Jean-Marc Lemaitre, Inserm researcher at the Functional Genomics Institute (Inserm/CNRS/Université de Montpellier 1 and 2), has recently succeeded in rejuvenating cells from elderly donors (aged over 100). These old cells were reprogrammed in vitro to induced pluripotent stem cells (iPSC) and to rejuvenated and human embryonic stem cells (hESC): cells of all types can again be differentiated after this genuine “rejuvenation” therapy. The results represent significant progress for research into iPSC cells and a further step forwards for regenerative medicine. Continue reading

St. Michael’s Hospital First to Use Novel Blood-Cleaning Procedure for Kidney Transplant

St. Michael’s Hospital today became the first in North America to use a novel blood-cleaning procedure for a kidney patient that will allow him to receive a transplant from a donor with a different blood type.

Transplants involving a donor and recipient with different blood types are rare. Most people have natural antibodies in their blood that would cause their immune system to reject an organ from someone with a different blood type.

The procedure used today is called plasmapheresis and is similar to kidney dialysis, which removes waste products from the blood. Plasmapheresis separates plasma from patient’s blood, and runs it through a column-shaped device containing synthetic carbohydrate beads that trap the blood group antibodies. Continue reading