When thinking about the health issues that we struggle with and worry about most in North America, cancer and dementia are likely near the top of the list. Even though heart disease is a major threat, it’s the thought of us or someone we know getting cancer or Alzheimer’s that seems to be a major preoccupation. These two diseases are front and center in the media day after day. Continue reading
When it comes to maintaining good health, people differ on what to focus on. Some concentrate on keeping a healthy body weight. For others, good digestion is a priority. Or, it could be that mental health becomes a focal point. Despite these different priorities, just about everyone agrees that maintaining good eyesight is very important. Being able to see clearly is a tremendous gift that we should all invest a little time and effort into protecting. Continue reading
L-carnitine is a non-essential amino acid that is made by the kidney and the liver and is derived from the amino acids methionine and lysine. Carnitine plays an important role in transporting long-chained fatty acid across the mitochondrial membranes in cell in order to produce energy. Recent research has determined that carnitine may play a role in lowering cholesterol and triglyceride levels, as well as improving cardiac performance.
What is L-carnitine used for?
L-carnitine has been used as a supplementative treatment in patients who have high cholesterol levels. Previous research has also indicated its use in cardiovascular disease, infertility, enhancement of athletic performance, and weight loss.
Where is L-carnitine normally found?
There is enough arginine made by your body, so supplementation is not generally required. It is also found in a variety of meat and dairy products.
How much do I take to lower my cholesterol levels?
There is currently no RDI established for L-carnitine, however, doses tend to average between 500 and 2000 mg a day.
How do I know if I am deficient in carnitine?
Arginine deficiency is rare, since your body makes the arginine it needs. Symptoms of a carnitine deficiency include muscle weakness, stiffness, or soreness, impaired glucose control, high cholesterol and dark reddish-brown urine. These symptoms could be the symptoms of antoher disorder, so you should consult your health care practitioner if you experience any of these symptoms.
Who should not take carnitine?
· Individuals who are taking valproic acid or zidovudine, since these drugs can deplete carnitine from the body. · Individuals with liver disease should consult their health care practitioner or pharmacist before taking L-carnitine. · If you have an underlying condition, or on other medications, be sure to consult with a pharmacist or your health care practitioner before you begin to take arginine.
Other names: lipoic acid, thioctic acid, ALA
Alpha lipoic acid is a fatty acid found naturally inside every cell in the body. It’s needed by the body to produce the energy for our body’s normal functions. Alpha lipoic acid converts glucose (blood sugar) into energy.
Alpha lipoic acid is also an antioxidant, a substance that neutralizes potentially harmful chemicals called free radicals. What makes alpha lipoic acid unique is that it functions in water and fat, unlike the more common antioxidants vitamins C and E, and it appears to be able to recycle antioxidants such as vitamin C and glutathione after they have been used up. Glutathione is an important antioxidant that helps the body eliminate potentially harmful substances. Alpha lipoic acid increases the formation of glutathione.
Alpha lipoic acid is made by the body and can be found in very small amounts in foods such as spinach, broccoli, peas, Brewer’s yeast, brussel sprouts, rice bran, and organ meats. Alpha lipoic acid supplements are available in capsule form at health food stores, some drugstores, and online. For maximum absorption, the supplements should be taken on an empty stomach.
Why People Use Alpha Lipoic Acid
Peripheral neuropathy can be caused by injury, nutritional deficiencies, chemotherapy or by conditions such as diabetes, Lyme disease, alcoholism, shingles, thyroid disease, and kidney failure. Symptoms can include pain, burning, numbness, tingling, weakness, and itching.
Alpha lipoic acid is thought to work as an antioxidant in both water and fatty tissue, enabling it to enter all parts of the nerve cell and protect it from damage.
Preliminary studies suggest that alpha lipoic acid may help. In one of the largest studies on the use of alpha lipoic acid, 181 people took 600 mg, 1200 mg or 1800 mg of alpha lipoic acid a day or a placebo. After 5 weeks, alpha lipoic acid improved symptoms. The dose that was best tolerated while still providing benefit was 600 mg once daily.
Alpha lipoic acid can cross the blood-brain barrier, a wall of tiny vessels and structural cells, and pass easily into the brain. It is thought to protect brain and nerve tissue by preventing free radical damage.
As an antioxidant, alpha lipoic acid can neutralize free radicals which can damage cells. Free radical damage is thought to contribute to aging and chronic illness.
Alpha lipoic acid has also been suggested for cataracts, glaucoma, multiple sclerosis, burning mouth syndrome, Alzheimer’s disease and stroke, but large, well-designed studies are needed to see if it’s effective for these conditions.
Side effects of alpha lipoic acid may include headache, tingling or a “pins and needles” sensation, skin rash, or muscle cramps.
There have been a few reports in Japan of a rare condition called insulin autoimmune syndrome in people using alpha lipoic acid. The condition causes hypoglycemia and antibodies directed against the body’s own insulin without previous insulin therapy.
The safety of alpha lipoic acid in pregnant or nursing women, children, or people with kidney or liver disease is unknown.
Possible Drug Interactions
Alpha lipoic acid may improve blood sugar control, so people with diabetes who are taking medication to lower blood sugar, such as metformin (Glucophage), glyburide (DiaBeta, Glynase), should only take alpha lipoic acid under the supervision of a qualified health professional and have their blood sugar levels carefully monitored.
Animal studies indicate that alpha lipoic acid may alter thyroid hormone levels, so it could theoretically have the same effect in humans. People taking thyroid medications such as levothyroxine should be monitored by their healthcare provider.