If you’re looking to reduce your risk of dementia, you might be increasing your intake of blueberries and omega-3 rich foods, but a new study shows another very important step you should take: avoid anticholinergic medication. Continue reading
A favorite herbal medicine of the ancients, peppermint leaves have been found in Egyptian pyramids dating back to 1,000 BC. Modern scientific investigations have now confirmed that this remarkable plant has over a dozen healing properties.
In our continuing effort to educate folks to the vast array of healing agents found in the natural world around us, Continue reading
More evidence has emerged showing the complete failure of modern vaccines to provide any real protection against disease. A recent study published in The New England Journal of Medicine (NEJM) reveals that an astounding 97 percent of children affected by a mumps outbreak that swept the Northeast back in 2009 had already been vaccinated for the condition in accordance with recommended government guidelines. Continue reading
Antidepressant Found to be Just as Effective as Placebo in Child Pain Relief
“Many pharmaceutical products are prescribed for off-label use in children due to the lack of clinical trials testing the efficacy of the drugs in children and adolescents. Therefore, the pediatric gastroenterologist frequently has to make treatment decisions without the evidence of how drugs work in children,” said
“The high placebo effect we identified in this study suggests that further studies of the use of certain antidepressants in children with functional bowel disorders are needed. While several trials have demonstrated a beneficial effect of antidepressants, including amitriptyline, for the treatment of irritable bowel syndrome (IBS) in adults, more research is needed to determine how effective this drug is, if at all, in children,” Dr. Saps added.
According to background information in an article on the study, published in the journal Gastroenterology, amitriptyline is used to treat symptoms of depression, but it is some times prescribed to children for pain relief from pain-predominant functional gastrointestinal disorders (FGIDs).
Pain-predominant FGIDs are among the most common causes for medical consultation in children. Such disorders include three common conditions: IBS, functional dyspepsia and functional abdominal pain.
For their study, the researchers designed a large prospective, multi-centre, randomised placebo-controlled trial in which children, ages eight to 17, with IBS, functional abdominal pain or functional dyspepsia were randomised to four weeks of placebo or amitriptyline.
Of the 83 children who completed the study, 63 percent of those who took amitriptyline reported feeling better, while 5 percent reported feeling worse.
Among those given a placebo, 57.5 percent felt better, while 2.5 percent felt worse.
Pain relief was excellent (7 percent), good (38 percent) in children on placebo and excellent (15 percent), good (35 percent) in children on amitriptyline.
The researchers observed that both amitriptyline and placebo were associated with excellent therapeutic response, although patients with mild to moderate intensity of pain responded better to treatment.
According to them, there was no significant difference between amitriptyline and placebo after four weeks of treatment.
In children, the use of drugs to treat pain-predominant FGIDs is mostly empirical and based on adult data.
There have been only a few small, randomized clinical trials evaluating the efficacy of drugs for the treatment of pain-predominant FGIDs in children.