According to bioweapons expert Francis Boyle, evidence suggests COVID-19 is a weaponized coronavirus originating from the Biosafety Level 4 facility in Wuhan City, China
COVID-19 appears to be a chimera consisting of SARS (an already weaponized coronavirus), HIV genetic material and influenza virus, designed with gain of function properties that allow it to spread a greater distance than normal
Others have suggested COVID-19 may involve Prevotella, a bacterium known to cause respiratory tract infections, and that this may explain some of the observed symptoms and how it can spread through feces
RNA sequencing data from Wuhan show millions of Prevotella proteins amid a few thousand COVID-19 viruses. Prevotella bacteria was also found in six COVID-19 patients from the same family in Hong Kong
Supplements thought to be useful in the prevention of coronavirus infection include NAC, elderberry, spirulina, beta-glucan, glucosamine, selenium, zinc, lipoic acid, sulforaphane, resveratrol, vitamin D, Bifidobacterium bifidum strain probiotics and sporebiotics
Food versus medicine is a battle that’s been waged for decades or more, but it’s been picking up in the last number of years. People like you are looking for alternative, safe treatments to health conditions without having to rely on the unknowns of pharmaceuticals.
Over the past decade, the natural supplement chondroitin has risen into discussion about treating joint pain. It is often teamed with glucosamine for this effect. A great piece of health news has just come out, suggesting that chondroitin sulfate improves hand function and relieves morning stiffness caused by osteoarthritis.
Osteoarthritis is the world’s leading cause of joint pain. It is caused by the gradual deterioration of cartilage in a joint. The disease affects more than 27 million adults in the U.S., causing pain and stiffness. Approximately 10% of the world population, 60 years and older, have symptomatic osteoarthritis. And prior studies have found that 20% to 30% of adults have osteoarthritis of the hand, with the prevalence rising to more than 50% after 60 years of age. Continue reading →
WASHINGTON – Scientists hope that laser-based processes may help create arterial stents and longer-lasting medical implants 10 times faster, and less expensively.
Yung Shin, a professor of Mechanical Engineering and director of Purdue’s Center for Laser-Based Manufacturing, stresses the need for new technologies to meet the huge global market for artificial hips and knees, insisting that the worldwide population of people younger than 40 who receive hip implants is expected to be 40 million annually by 2010, and double to 80 million by 2030.
Besides speeding production to meet the anticipated demand, Shin says that another goal is to create implants that last longer than the ones that are made presently.
“We have 200,000 total hip replacements in the United States. They last about 10 years on average. That means if you receive an implant at 40, you may need to have it replaced three or four times in your lifetime,” he said.
In one of their techniques, the researchers deposit layers of a powdered mixture of metal and ceramic materials, melting the powder with a laser and then immediately solidifying each layer to form parts.
Shin says that, given that the technique enables parts to be formed one layer at a time, it is ideal for coating titanium implants with ceramic materials that mimic the characteristics of natural bone.
“Titanium and other metals do not match either the stiffness or the nature of bones, so you have to coat it with something that does. However, if you deposit ceramic on metal, you don’t want there to be an abrupt change of materials because that causes differences in thermal expansion and chemical composition, which results in cracks. One way to correct this is to change the composition gradually so you don’t have a sharp boundary,” Shin said.
The gradual layering approach is called a “functionally gradient coating”.
The researchers have revealed that they used their laser deposition processes to create a porous titanium-based surface and a calcium phosphate outer surface, both designed to better match the stiffness of bone than conventional implants.
The laser deposition process enables researchers to make parts with complex shapes that are customized for the patient.
“Medical imaging scans could just be sent to the laboratory, where the laser deposition would create the part from the images. Instead of taking 30 days like it does now because you have to make a mold first, we could do it in three days. You reduce both the cost and production time,” Shin said.
According to the researchers, the laser deposition technique lends itself to the requirement that each implant be designed specifically for each patient.
“These are not like automotive parts. You can’t make a million that are all the same,” Shin said.
He says that the process creates a strong bond between the material being deposited and the underlying titanium, steel or chromium.
The researcher further reveals that tests have shown that the bond is at least seven times as strong as industry standards require.
Using computational modelling, the researchers simulate, study and optimise the processes.
The researchers, however, admit that more studies are required before the techniques are ready for commercialisation.
They have revealed that their future work will involve studying “shape-memory” materials that are similar to bone and also have a self-healing capability for longer-lasting implants.
They are also working on a technique that uses an “ultra short pulse laser” to create arterial stents, which are metal scaffolds inserted into arteries to keep them open after surgeries to treat clogs.
Since the laser pulses last only a matter of picoseconds, or quadrillionths of a second, they do not cause heat damage to the foil-thin stainless steel and titanium material used to make the stents.
The laser removes material in precise patterns in a process called “cold ablation”, which turns solids into a plasma. The patterns enable the stents to expand properly after being inserted into a blood vessel.
BIRMINGHAM – Can bacteria help build bones implants? Well, at least scientists at the University of Birmingham say “Yes”.
Lead researcher LynneMacaskie suggests that Serratia bacteria that manufacture hydroxyapatite (HA) could be used to make stronger, more durable bone implants.
In a study, the researchers showed that the bacterial cells stuck tightly to surfaces like as titanium alloy, polypropylene, porous glass and polyurethane foam by forming a biofilm layer containing biopolymers that acted as a strong adhesive.
The HA coating then builds up over the surface. For practical use, the HA layer must stick tightly, then the material is dried and heated to destroy the bacteria.
With the help of micro-manipulation technique, the researchers measured the force needed to overcome the bioglue adhesion, and showed that dried biofilm stuck 20-times more tightly than fresh biofilm.
When coated with HA the adhesion was several times more again. Slightly roughening the surface made the bioglue much more effective.
Presently, implant materials are made by spraying-on hydroxyapatite. This does not have good mechanical strength and the spraying only reaches visible areas.
The new biocoating method reaches all the hidden surfaces as the bacteria can “swim” into hidden nooks and crannies.
Macaskie insists that bacterial HA has better properties than HA made chemically as the nanocrystals of HA produced by the bacteria are much smaller than HA crystals produced chemically, giving them a high mechanical strength.
“The bacteria are destroyed by heating, leaving just the HA stuck to the surface with their own glue – rather akin to a burnt milk-saucepan,” said Macaskie.
“We need to do more work actually to turn the materials into materials we can use in biomedicine and the environment,” she added.
The study was presented at Society for General Microbiology’s meeting at Heriot-Watt University, Edinburgh.
“The boomer and senior population is growing, so joint and bone health are top of mind for that demographic,” says Mintel’s KristaFaron, senior new-product analyst. “When it comes to supplements, calcium, vitamin D and magnesium dominate for bone health. Glucosamine, chondroitin and omega-3s are dominating the joint category. These traditional ingredients will continue to dominate but unexpected forms will emerge.”
For example, Bonemilk, a milk product with extra calcium plus glucosamine, was just recently launched. However, Minute Maid Active with glucosamine — despite the marketing heft of a leading mainstream brand — was pulled from the shelves after two years on the market. Formulators are also taking traditional joint-health ingredients and re-orienting them to the performance field, as with Vuel grape sports drink, a joint-rejuvenating beverage containing glucosamine, MSM and electrolytes.
“Once you move away from pills, joint health is an untapped area for joint-health drinks and foods,” Faron says. More consumers are now turning to foods — up 29 per cent— and beverages — up 11 per cent — fortified with joint-health ingredients, according to Nielsen data.
A compelling option is type II collagen, an ingredient that provides a naturally occurring matrix of chondroitin sulphate, hyaluronic acid and hydrolysed collagen type II, as well as glucosamine and other proteoglycans. Its dollar sales in 2007 were up 98.75 per cent, accoding to Nutrition Business Journal.
MSM, third in ingredient sales for the category, is worth $5 million. “A strong evidence base supports the utility of MSM for the promotion of joint health,” says TonyKeller, president of TandemRain Innovations, supplier of ActivMSM. “With ActivMSM being FDA GRAS, we see a significant opportunity for the entry of MSM into conventional foods and beverages, extending its joint-health pedigree and ushering in new applications for cardiovascular health. The suggestion of MSM being a sulphur metabolism modifier also opens up platforms for skin/hair/nails applications.” Beyond these major players, there is no shortage of ingredients looking to get in on the joint-health action.
Glucosamine is a compound found naturally in the body, made from glucose and the amino acid glutamine. Glucosamine is needed to produce glycosaminoglycan, a molecule used in the formation and repair of cartilage and other body tissues. Production of glucosamine slows with age.
Glucosamine is available as a nutritional supplement in health food stores and many drug stores. Glucosamine supplements are manufactured in a laboratory from chitin, a substance found in the shells of shrimp, crab, lobster, and other sea creatures. In additional to nutritional supplements, glucosamine is also used in sports drinks and in cosmetics.
Glucosamine is often combined with chondroitin sulfate, a molecule naturally present in cartilage. Chondroitin gives cartilage elasticity and is believed to prevent the destruction of cartilage by enzymes. Glucosamine is sometimes combined with methylsulfonylmethane, or MSM, in nutritional supplements.
Why Do People Use Glucosamine?
Glucosamine supplements are widely used for osteoarthritis, particularly knee osteoarthritis. In osteoarthritis, cartilage — the rubbery material that cushions joints — becomes stiff and loses its elasticity. This makes the joint prone to damage and may lead to pain, swelling, loss of movement, and further deterioration.
Since the body’s natural glucosamine is used to make and repair joint cartilage, taking glucosamine as a nutritional supplement is thought to help repair damaged cartilage by augmenting the body’s supply of glucosamine.
There is promising evidence that glucosamine may reduce pain symptoms of knee osteoarthritis and possibly slow the progression of osteoarthritis. For example, a study published in the journal Archives of Internal Medicine examined people with osteoarthritis over three years. Researchers assessed pain and structural improvements seen on x-ray. They gave 202 people with mild to moderate osteoarthritis 1,500 mg of glucosamine sulfate a day or a placebo.
At the end of the study, researchers found that glucosamine slowed the progression of knee osteoarthritis compared to the placebo. People in the glucosamine group had a significant reduction in pain and stiffness. On x-ray, there was no average change or narrowing of joint spaces in the knees (a sign of deterioration) of the glucosamine group. In contrast, joint spaces of participants taking the placebo narrowed over the three years.
One of the largest studies on glucosamine for osteoarthritis was a 6-month study sponsored by the National Institutes of Health. Called GAIT, the study compared the effectiveness of glucosamine hydrochloride (HCL), chondroitin sulfate, a combination of glucosamine and chondroitin sulfate, the drug celecoxib (Celebrex), or a placebo in people with knee osteoarthritis.
Glucosamine or chondroitin alone or in combination didn’t reduce pain in the overall group, although people in the study with moderate-to-severe knee pain were more likely to respond to glucosamine.
One major drawback of the GAIT Trial was that glucosamine hydrochloride was used rather than the more widely used and researched glucosamine sulfate. A recent analysis of previous studies, including the GAIT Trial, concluded that glucosamine hydrochloride was not effective. The analysis also found that studies on glucosamine sulfate were too different from one another and were not as well-designed as they should be, so they could not properly draw a conclusion. More research is needed.
Still, health care providers often suggest a three month trial of glucosamine and discontinuing it if there is no improvement after three months. A typical dose for osteoarthritis is 1,500 mg of glucosamine sulfate each day.
Other conditions for which glucosamine is used include rheumatoid arthritis, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), chronic venous insufficiency, and skin conditions, although further evidence is needed.
Side Effects and Safety of Glucosamine
Most studies involving humans have found that short-term use of glucosamine is well-tolerated. Side effects may include drowsiness, headache, insomnia, and mild and temporary digestive complaints such as abdominal pain, poor appetite, nausea, heartburn, constipation, diarrhea, and vomiting. In rare human cases, the combination of glucosamine and chondroitin has been linked with temporarily elevated blood pressure and heart rate and palpitations.
Since glucosamine supplements may be made from shellfish, people with allergies to shellfish should avoid glucosamine unless it has been confirmed that it is from a non-shellfish source. The source of glucosamine is not required to be printed on the label, so it may require a phone call to the manufacturer.
There is some evidence suggesting that glucosamine, in doses used to treat osteoarthritis, may worsen blood sugar, insulin, and/or hemoglobin A1c (a test that measures how well blood sugar has been controlled during the previous three months) levels in people with diabetes or insulin resistance.
Theoretically, glucosamine may increase the risk of bleeding. People with bleeding disorders, those taking anti-clotting or anti-platelet medication, such as warfarin, clopidogrel, and Ticlid, or people taking supplements that may increase the risk of bleeding, such as garlic, ginkgo, vitamin E, or red clover, should not take glucosamine unless under the supervision of a healthcare provider.
The safety of glucosamine in pregnant or nursing women isn’t known.
NEW ORLEANS – Based on human research, there is good evidence to support the use of glucosamine sulfate in the treatment of mild-to-moderate knee osteoarthritis. Most studies have used glucosamine sulfate supplied by one European manufacturer (Rotta Research Laboratorium), and it is not known if glucosamine preparations made by other manufacturers are equally effective. Although some studies of glucosamine have not found benefits, these have either included patients with severe osteoarthritis or used products other than glucosaminesulfate . The evidence for the effect of glycosaminoglycan polysulphate is conflicting and merits further investigation. More well-designed clinical trials are needed to confirm safety and effectiveness, and to test different formulations of glucosamine.
Several human studies and animal experiments report benefits of glucosamine in treating osteoarthritis of various joints of the body, although the evidence is less plentiful than that for knee osteoarthritis. Some of these benefits include pain relief, possibly due to an anti-inflammatory effect of glucosamine, and improved joint function. Overall, these studies have not been well designed. Although there is some promising research, more study is needed in this area before a firm conclusion can be made.
Chronic venous insufficiency
“Chronic venous insufficiency” is a syndrome that includes leg swelling, varicose veins, pain, itching, skin changes, and skin ulcers. The term is more commonly used in Europe than in the United States. Currently, there is not enough reliable scientific evidence to recommend glucosamine in the treatment of this condition.
Diabetes (and related conditions)
Early research suggests that glucosamine does not improve blood sugar control, lipid levels, or apolipoprotein levels in diabetics. Additional research is needed in this area.
Preliminary research reports improvements with N-acetyl glucosamine as an added therapy in inflammatory bowel disease. Further scientific evidence is necessary before a strong recommendation can be made.
Pain (leg pain)
Preliminary human research reports benefits of injected glucosamine plus chondroitin in the treatment of leg pain arising from advanced lumbar degenerative disc disease. Further scientific evidence is necessary before a firm recommendation can be made.
Rehabilitation (after knee injury)
Glucosamine has been given to athletes with acute knee injuries. Although glucosamine did not improve pain, it did help improve flexibility. Additional research is needed to confirm these early findings.
Early human research reports benefits of glucosamine in the treatment of joint pain and swelling in rheumatoid arthritis. In other research, glucosamine did not exert anti-rheumatic effects, but it did improve symptoms of the disease. However, this is early information, and additional research is needed before a conclusion can be drawn. The treatment of rheumatoid arthritis can be complicated, and a qualified healthcare provider should follow patients with this disease.