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Jerusalem scientists identify molecular basis for DNA breakage, which results in the development of cancer.
The molecular basis for the breakage of DNA – the hallmark of cancer cells – has been identified by Hebrew University of Jerusalem scientists. The important discovery will be published on Friday in the prestigious journal Molecular Cell.
The DNA encodes all the genetic information needed to build the cell’s proteins. Thus, breaks in the DNA disrupt the proteins and lead to changes in cell function. These changes can lead to defects in the control of cellular proliferation, which results in the development of cancer.
Using cutting-edge technologies, researchers Prof. Batsheva Kerem and doctoral student Efrat Ozeri-Galai, of the Alexander Silverman Institute of Life Sciences in the HU’s Faculty of Science, were able to characterize for the first time the DNA regions that are the most sensitive to breakage in early stages of cancer development.
This is a breakthrough in our understanding of the effect of the DNA sequence and structure on its replication and stability, they said on Thursday. Continue reading