New Findings on Therapeutic Hypothermia Following Cardiac Arrest in Children

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Intravenous delivery of cold fluids to reduce body temperature quickly after a heart attack and improve neurologic outcomes may not be as effective in children as it is in adults, according to a study reported in Therapeutic Hypothermia and Temperature Management, a peer-reviewed journal published by Mary Ann Liebert, Inc. The article is available free online at www.liebertpub.com/ther

In adults, therapeutic hypothermia to minimize neurological complications caused by cardiac arrest can be achieved by rapidly infusing cold (4oC) intravenous fluid. However, this might not be the optimal approach in children. Alexis Topjian, Michael Hamid, Larissa Hutchins, and Vinay Nadkarni, The Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, studied the effect of the infusion rate on the temperature of the cold IV fluid in three simulated pediatric patients of different weights. They describe the study design and their results in the article entitled, “Can a Cold (4oC) IV Fluid Bolus to Induce Therapeutic Hypothermia Really Deliver 4oC to Children?”

“This is an important and timely contribution because it reinforces the point that children are not just small people Continue reading

St. John’s Wort Compound Discovered as Promising Treatment for Incurable Brain Tumor

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Around 10,000 Americans are diagnosed with a malignant glioma every year. And, unfortunately, they received an almost inevitable death sentence. Glioma, types of tumors which grow in the brain or spine, are virtually incurable and the average one-year survival rate after diagnosis is only about 50 percent.

But now there is finally hope for a new and effective treatment. A compound known as hypericin, originally discovered in the herb St. John’s wort.

In findings just published in the journal Cancer, scientists are reporting that synthetic hypericin strongly inhibits the growth of gliomas. The reason appears to be, at least in part, because hypericin inhibits proteinĀ  Continue reading