Dr. Cameron Kyle-Sidell, MD is a board-certified emergency medicine physician in Brooklyn, New York. He is affiliated with Maimonides Medical Center and is crying out that something is not right in ICU departments across America in terms of how they are treating coronavirus patients. Continue reading
Over the years, there has been plenty of research performed on the value of natural substances in treating human diseases, but very little has been conducted on the effects of commonly used supplements and/or food components such as spices in already healthy people to improve their well-being. Continue reading
A new study shows that vigorously exercising at least four times per week can reduce your risk of a stroke, especially if you’re a man; the results are unclear if you’re a woman
This study (and some prior studies) seem to suggest that women Continue reading
Turmeric is a spice derived from the rhizomes of Curcuma longa, a member of the ginger family. Curcuminoids are polyphenolic compounds that give turmeric its yellow color; curcumin is the principal curcuminoid in turmeric.
The results of phase I clinical trials in colorectal cancer patients suggest that biologically active levels Continue reading
Drinking beetroot juice can boost your stamina and athletic performance, scientific studies have confirmed.
One of the first such studies, conducted by researchers from the University of Exeter and published in the Journal of Applied Physiology in 2010, looked at seven men who consumed either 500 mL per day of beetroot juice Continue reading
If your blood pressure is not where you want it to be.
If you’ve done everything right, but haven’t gotten the results you want.
Then please take five minutes to read this report. I believe I’ve found the solution you’ve been hoping for. Continue reading
Mitochondria, tiny cell structures that power our muscles, can develop leaks that hurt muscle performance. Research shows, however, that substances found in spinach can stop these leaks and make mitochondria mightier. But to get the full effect, you may have to ditch your mouthwash. Strong mouthwashes kill off the oral bacteria that enable the body to put spinach’s Continue reading
Popeye famously ate spinach when in a jam to instantly build his biceps and gain the strength to save a damsel in distress. Well, a new study conducted at North Carolina State University suggests that he may have been better off eating mustard greens. Continue reading
Dracula had it right. The blood IS the key to longevity. In this age of global contamination and health care meltdown, the practice of blood cultivation must be rightly understood by anyone interested in health self sufficiency and longevity.
Time and time again, people do not heal at the core of their imbalance. This is because the quality of their blood has not been properly cultivated. The blood is the river of life in the body. When we cultivate our blood, we establish the foundation that promotes health, wellness and longevity.
THE PRACTICE OF CULTIVATING OUR BLOOD
There are two aspects to the practice Continue reading
After taking a small dose of inorganic nitrate for three days, healthy people consume less oxygen while riding an exercise bike. A new study in the February issue of Cell Metabolism traces that improved performance to increased efficiency of the mitochondria that power our cells.
The researchers aren’t recommending anyone begin taking inorganic nitrate supplements based on the new findings. Rather, they say that the results may offer one explanation for the well-known health benefits of fruits and vegetables, and leafy green vegetables in particular.
“We’re talking about an amount of nitrate equivalent to what is found in two or three red beets or a plate of spinach,” said Eddie Weitzberg of the Karolinska Institutet in Sweden. “We know that diets rich in fruits and vegetables can help prevent cardiovascular disease and diabetes but the active nutrients haven’t been clear. This shows inorganic nitrate as a candidate to explain those benefits.”
In fact, up until recently nitrate wasn’t thought to have any nutritional value at all. It has even been suggested that this component of vegetables might be toxic. But Weitzberg and his colleague Jon Lundberg earlier showed that dietary nitrate feeds into a pathway that produces nitric oxide with the help of friendly bacteria found in our mouths. Nitric oxide has been known for two decades as a physiologically important molecule. It opens up our blood vessels to lower blood pressure, for instance.
The new study offers yet another benefit of nitrate and the nitric oxides that stem from them. It appears that the increased mitochondrial efficiency is owed to lower levels of proteins that normally make the cellular powerhouses leaky. “Mitochondria normally aren’t fully efficient,” Weitzberg explained. “No machine is.”
Questions do remain. The new results show that increased dietary nitrate can have a rather immediate effect. But it’s not yet clear what might happen in people who consume higher levels of inorganic nitrate over longer periods of time. Weitzberg says it will be a natural next step to repeat the experiment in people with conditions linked to mitochondrial dysfunction, including diabetes and cardiovascular disease, to see if they too enjoy the benefits of nitrates.
“Among the more consistent findings from nutritional research are the beneficial effects of a high intake of fruit and vegetables in protection against major disorders such as cardiovascular disease and diabetes,” the researchers concluded. “However, the underlying mechanism(s) responsible for these effects is still unclear, and trials with single nutrients have generally failed. It is tempting to speculate that boosting of the nitrate-nitrite-NO pathway may be one mechanism by which vegetables exert their protective effects.”
As an interesting aside, Weitzberg says that the benefits of dietary nitrates suggest that powerful mouthwashes may have a downside. “We need oral bacteria for the first step in nitrate reduction,” he says. “You could block the effects of inorganic nitrate if you use a strong mouthwash or spit [instead of swallowing your saliva]. In our view, strong mouthwashes are not good if you want this system to work.”
ITHICA – Scientists from Weill Cornell Medical College have identified certain compounds that would inhibit the sophisticated mechanism used by tuberculosis bacteria for surviving dormant in infected cells.
The researchers said most of the people infected with TB remain symptom-free because the Mycobacterium tuberculosis, the disease-causing bacteria, is kept in check within immune system cells.
These cells produce compounds such as nitric oxide, which scientists believe damage or destroy the bacteria’s proteins. If these compounds are allowed to accumulate, the damaged proteins would kill the bacteria.
However, a protein-cleaving complex known as a proteasome breaks down that damaged proteins and allows the bacteria to remain dormant.
The researchers suggest that finding drugs to disable the proteasome would be a new way to fight TB.
During the study, the researchers examined 20,000 compounds for TB proteasome inhibition activity, and identified and synthesized a group of inhibitors, which they then tested for their ability to inhibit the proteasome inside the mycobacteria.
“We believe these findings represent a new approach for developing antibiotics in the fight against TB,” Nature magazine quoted Dr. Carl Nathan, senior author and chairman of the Department of Microbiology and Immunology, R.A. Rees Pritchett Professor of Microbiology and director of the Abby and Howard P.
Milstein Program in Chemical Biology of Infectious Disease at Weill Cornell Medical College, as saying
“This is important because we are running out of effective antibiotics that are currently available. There are few drugs that successfully combat TB in its dormant stage, which makes the bacterium so resilient in the body.
“More important, there are many antibiotics that kill bacteria by blocking the synthesis of proteins, but there are none that kill bacteria by interfering with protein breakdown, as we have found here,”
DETROIT – Michigan researchers have developed a powerful new GPS-like tool to identify proteins that are affected by a chemical process that is key to aging and disease development.
The probe, which works like a GPS or navigation system for finding these proteins in cells, could lead to new insights into disease processes and identify new targets for disease treatments, according to the researchers.
It is believed that a diet rich in antioxidants, which are abundant in fruits and vegetables, may help cease this cell-damaging process by blocking the accumulation of these molecules, also known as reactive oxygen species (ROS).
However, to date, scientists have not found any proper tools to study the effects of these molecules in detail.
Thus, the researchers developed a new molecule called DAz-2, which, according to them, functions like a tiny GPS device for quickly finding specific proteins that are affected by ROS.
The molecules do this by chemically “tagging” sulfenic acid, which is formed in cells and indicates that a protein has undergone a type of reaction – called oxidation – caused by ROS.
In lab studies using cultured cells, the scientists identified more than 190 proteins that undergo this reaction.
The researchers said that the study could lead to better strategies for fighting the wide range of diseases that involve these excessive oxidation reactions.
The study will be published in ACS Chemical Biology, a monthly journal
YAOUNDE – Gorillas carry the parasite that causes malignant malaria in humans, a finding that could help in efforts to develop a vaccine for malaria, researchers say.
Malaria is a sometimes fatal disease, usually contracted from mosquitoes, most commonly in areas such as sub-Saharan Africa and South Asia. People who contract malaria typically develop flu-like symptoms with high fevers and chills, according to the U.S. Centers for Disease Control and Prevention.
In the new study, researchers analyzed fecal samples from 84 gorillas in Cameroon and blood samples from three gorillas in Gabon and found the parasite Plasmodium falciparum, which was previously believed to only infect humans. P. falciparum causes 85 percent of malignant malaria infections in humans and nearly all deaths from malaria.
The scientists also found that the gorillas carried two closely related species of malaria parasites: Plasmodium GorA and Plasmodium GorB.
The discovery of P. falciparum in gorillas complicates efforts to eradicate malaria, according to the study published in this week’s issue of the Proceedings of the National Academy of Sciences.
“Hundreds of billions of dollars are spent each year toward ridding humans of malignant malaria. But success may be a pyrrhic victory, because we could be re-infected by gorillas — just as we were originally infected by chimps a few thousand years ago,” study co-author Francisco Ayala, a biologist at the University of California, Irvine, said in a university news release.
Along with potentially aiding in the development of a malaria vaccine, this finding helps improve understanding of how infectious diseases such as HIV, SARS and bird and swine flu can be transmitted from animals to humans, the researchers noted.
Each year, malaria sickens about 500 million people worldwide and causes 2 million infant deaths. Four kinds of malaria parasites can infect humans: P. falciparum, P. vivax, P. ovale, P. malariae. Infection with P. falciparum, if not promptly treated, may lead to death, according to the CDC.
Soon, Robo-Bees that Mimic Bees Behavior
The project will draw on the knowledge of computer scientists, engineers, and biologists to construct an electronic nervous system, a supervisory architecture and a high-energy source to power the innovative robots.
“This project will integrate the efforts and expertise of a diverse team of investigators to create a system that far transcends the sum of its parts. We expect substantial advances in basic science at the intersection of these seemingly disparate disciplines to result from this effort,” said Ayers.
Inspired by the biology of the bee and the insect’s colonial behaviour, the project aims to advance miniature robotics and the design of compact high-energy power sources.
The project would also spur innovations in ultra-low-power computing and electronic “smart” sensors that mediate biomimetic control.
In addition, it would refine coordination algorithms to manage multiple, independent machines.
Ayers is widely known for his work in biomimetics- the science of adapting the control systems found in nature to inform design of engineered systems to solve real-world problems-including the development of RoboLobster and RoboLamprey.
The autonomous, biomimetic underwater robotic models emulate the operations of the animals’ nervous systems using an electronic controller based on nonlinear, moving models of neurons and synapses.
“Animals have evolved to occupy every environmental niche where we would hope to operate robots, save outer space. They provide proven solutions to problems that confound even the most sophisticated robots, and our challenge is to capture these performance advantages in engineered devices,” said Ayers.
The Pill Bottle Gets a Cell Phone, to Remind You to Take Your Medicine
CAMBRIDGE – “Hi! This is your aspirin bottle calling. I haven’t seen you in a while. Why don’t you come see me soon? I’m good for the heart, you know.”
That’s the spirit, if not the wording, of the calls that will come from new pill bottle caps that connect to AT&T Inc.’s wireless network.
A Cambridge, Mass.-based startup called Vitality Inc. was set to announce the pill-bottle system Thursday, saying it helps solve one of the biggest problems in medicine: that people don’t consistently take the drugs they’re prescribed.
That costs the U.S. $290 billion in added medical spending each year, according to a study published in August by the New England Healthcare Institute. Mortality rates are twice as high among diabetes and heart disease patients who don’t take their pills properly, it said.
With Vitality’s system, when a pill-bottle cap is opened, it uses a close-range wireless signal to tell a base station in the home. That station, which looks like a night light, essentially has a cell phone inside that can send messages through AT&T’s network.
If the bottle isn’t opened at the appointed time, the cap and night light start blinking to remind the owner to take the medication. If that doesn’t serve as enough of a hint, they start playing jingles as well. If the bottle stays unopened, the night light will send a message to Vitality’s system, which can then place an automated phone call or send a text message with a reminder.
That points to another possibility opened by the wireless bottle cap: making the pill-taking routine more than just a matter between the patient and the bottle. Vitality’s system can be set to alert a relative if someone isn’t taking medicine.
“The social aspect of this is important,”
A price for the new system hasn’t been disclosed. Vitality hopes insurance and drug companies will get on board with the system and cover the cost.
Vitality has been selling an earlier version of the product in small numbers from its Web site for $99. In that version, the night light doesn’t contain a cell phone. Instead it connects to a third piece of hardware, a “gateway” plugged into a home’s Internet router. But not all homes have routers, and configuring them can be tricky. The AT&T-powered night light simplifies the installation.