Buerger’s disease is caused by inflamed arteries and veins in the arms and in the legs. The inflammation leads to narrow and blocked blood vessels, resulting in a reduced blood flow and damage to the affected tissues. This disease is highly associated with cigarette and tobacco use – some component of tobacco poisons cells. A person with Buerger’s disease only aggravates it as he continues to smoke; the symptoms, however, are decreased once the person quits the habit. Other causes include genetics, blood clots (from other causes), and poor blood circulation.