Specialized Regulatory T Cell Stifles Antibody Production Centers

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Discovery has potential implications for cancer, autoimmune disease

A regulatory T cell that expresses three specific genes shuts down the mass production of antibodies launched by the immune system to attack invaders, a team led by scientists at The University of Texas MD Anderson Cancer Center reported online in the journal Nature Medicine.

“Regulatory T cells prevent unwanted or exaggerated immune system responses, but the mechanism by which they accomplish this has been unclear,” said paper senior author Chen Dong, Ph.D., professor in MD Anderson’s Department of Immunology and director of the Center for Inflammation and Cancer.

“We’ve identified a molecular pathway that creates a specialized regulatory T cell, which suppresses the reaction of structures called germinal centers. This is where immune system T cells and B cells interact to swiftly produce large quantities of antibodies,” Dong said. Continue reading