Natural Help for Erectile Dysfunction

The first step to naturally lowering your risk of impotence is to step out the door. Exercises like walking three hours per week drop your risk of having erectile dysfunction by 30 percent.1 And along with physical activity, a wide variety of herbs can also boost your sexual life.

The Value of Movement

If you’re an immovable object, your sex life isn’t likely to budge, either. An analysis of 31,742 men age 53 to 90 reported in the Annals of Internal Medicine in 2003 shows that exercise keeps you leaner and fit for sex, as well as mentally more ready for sexual interaction.

Stress Obstructions Continue reading

When Erectile Dysfunction isn’t Whole Story

For men with erectile dysfunction (ED), 65 percent are unable to have an orgasm and 58 percent have problems with ejaculation, according to new research led by physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center.

The study followed 12,130 men with mild to severe ED and is the largest-ever analysis of orgasmic and ejaculatory dysfunction. Results are published in today’s edition of the British Journal of Urology International.

Approximately 30 million American men, or half of all men aged 40 to 70, have trouble achieving or sustaining an erection. “While medications like Viagra or Cialis have been successful in helping many of these men, our research suggests there are other common sexual issues that remain largely unaddressed,” says Dr. Darius Paduch, the study’s lead author; male sexual medicine specialist at NewYork-Presbyterian Hospital/Weill Cornell Medical Center; and assistant professor of urology Continue reading

Natural Version of Viagra Found in a Chinese Herb

MILAN, ITALY- A Chinese herbal remedy known as “horny goat weed” may indeed live up to its name as a natural version of Viagra.

Italian researchers report that laboratory studies show that the compound has the potential to treat erectile dysfunction, and possibly with fewer side effects than its pharmaceutical cousin.

“No in-vivo studies in an animal model have been performed at this regard, so a lot of work must be done. We would like to test in vivo [with animals] the molecule to understand if it really works in humans,” said study lead author Mario Dell’Agli, of the University of Milan’s laboratory of pharmacognosy. “At this stage of the research, we cannot say if the molecule we have synthesized possesses less side effects with respect to Viagra. However, this derivative seems to be in vitro [in lab tests] more selective than Viagra, because it targets [an enzyme involved in blood flow to the penis] more precisely.”

The study was expected to be published in the Oct. 24 issue of the Journal of Natural Products, a publication of the American Chemical Society.

Viagra (sildenafil) is one of several prescription medications available and widely prescribed for erectile dysfunction, a condition that affects an estimated 18 million men in the United States. Viagra and other drugs like it can cause side effects such as headache, stomach problems and visual disturbances.

Horny goat weed, hailing primarily from southern China, has a long history as an aphrodisiac.

As part of a new screening program to find natural alternatives to Viagra, the study authors analyzed a number of herbal extracts long used for male impotence, including Ferula hermonis or Lebanese Viagra; Cinnamomum cassia or Chinese cinnamon; as well as Epimedium brevicornum aka horny goat weed. All three extracts are reputed to improve sexual performance.

The main active component of each extract was tested against an enzyme known as phosphodiesterase-5A1 (PDE5A1), which regulates blood supply to the penis. Inhibition of this enzyme results in more blood flow to the penis, resulting in an erection.

Icariin, the active ingredient of horny goat weed, inhibited PDE5A1 to a greater degree than the other compounds tested.

“The novelty of this work is the new molecule we have synthesized by icariin,” Dell’Agli said. “It is derived by chemical modifications of the structure of icariin, which is the active ingredient purified from E. brevicornum (horny goat weed). The mechanism by which the molecule we have found might work in humans is the inhibition of phosphodiesterase 5 (PDE 5) in the corpus cavernosum [erectile tissue in the penis], which is the mechanism by which Viagra works. This is an in vitro study. It can be considered a pre-clinical study.”

Viagra Compounds Found to Shrink Abnormally Large Hearts

ROCHESTER  – Compounds related to Viagra, already in clinical trials to prevent heart failure, may also counter the disease in a different way, says a new study.

The results hold promise for the design of a new drug class and for its potential use in combination with Viagra or beta blockers.

In heart failure, which affects about 5.7 million Americans, the heart gradually loses the ability to pump with enough force to supply the body with blood.

One reason for lost pumping strength is the mass death of heart muscle cells seen in many heart attacks. Fewer remaining muscle cells must then push around the same amount of blood, and hard working muscles grow.

Unlike the healthy bulging of an athlete’s bicep, abnormal muscle growth (pathogenic hypertrophy) in diseased hearts thickens chamber walls, slows the heartbeat and causes potentially fatal arrhythmias (erratic beats) and heart failure as well.

Recent efforts to reverse hypertrophy included a clinical trial, sponsored by Viagra manufacturer Pfizer, and the National Heart, Lung, and Blood Institute (NHLBI), where they looked at whether Viagra (sildenafil) can treat moderate heart failure and reduce hypertrophy.

Along with increasing blood flow in arteries, Viagra interferes with phosphodiesterases (PDEs), the enzymes that break down the messenger molecule called cyclic guanosine monophosphate (cGMP), which would otherwise restrain heart muscle cell growth.

“Our results suggest that a PDE1a inhibitor alone can shut down abnormal cardiac growth, and when combined with Viagra or beta blockers, may do so in more than one way,” said Chen Yan, associate professor cardiology, University of Rochester Medical Centre (URMC) and study co-author, says a Rochester release.

Yan’s lab is focused on revealing the role of various PDE enzymes in atherosclerosis and hypertension as well as in heart failure.

Could Chinese Herb Be a Natural Viagra?

Could Chinese Herb Be a Natural Viagra?

MILAN, ITALY-  A Chinese herbal remedy known as “horny goat weed” may indeed live up to its name as a natural version of Viagra.

Italian researchers report that laboratory studies show that the compound has the potential to treat erectile dysfunction, and possibly with fewer side effects than its pharmaceutical cousin.

“No in-vivo studies in an animal model have been performed at this regard, so a lot of work must be done. We would like to test in vivo [with animals] the molecule to understand if it really works in humans,” said study lead author Mario Dell’Agli, of the University of Milan’s laboratory of pharmacognosy. “At this stage of the research, we cannot say if the molecule we have synthesized possesses less side effects with respect to Viagra. However, this derivative seems to be in vitro [in lab tests] more selective than Viagra, because it targets [an enzyme involved in blood flow to the penis] more precisely.”

The study was expected to be published in the Oct. 24 issue of the Journal of Natural Products, a publication of the American Chemical Society.

Viagra (sildenafil) is one of several prescription medications available and widely prescribed for erectile dysfunction, a condition that affects an estimated 18 million men in the United States. Viagra and other drugs like it can cause side effects such as headache, stomach problems and visual disturbances.

Horny goat weed, hailing primarily from southern China, has a long history as an aphrodisiac.

As part of a new screening program to find natural alternatives to Viagra, the study authors analyzed a number of herbal extracts long used for male impotence, including Ferula hermonis or Lebanese Viagra; Cinnamomum cassia or Chinese cinnamon; as well as Epimedium brevicornum aka horny goat weed. All three extracts are reputed to improve sexual performance.

The main active component of each extract was tested against an enzyme known as phosphodiesterase-5A1 (PDE5A1), which regulates blood supply to the penis. Inhibition of this enzyme results in more blood flow to the penis, resulting in an erection.

Icariin, the active ingredient of horny goat weed, inhibited PDE5A1 to a greater degree than the other compounds tested.

 

“The novelty of this work is the new molecule we have synthesized by icariin,” Dell’Agli said. “It is derived by chemical modifications of the structure of icariin, which is the active ingredient purified from E. brevicornum (horny goat weed). The mechanism by which the molecule we have found might work in humans is the inhibition of phosphodiesterase 5 (PDE 5) in the corpus cavernosum [erectile tissue in the penis], which is the mechanism by which Viagra works. This is an in vitro study. It can be considered a pre-clinical study.”